DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302E1 and UGT2B7

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001065.2	Gene:	UGT2B7 / 7364	HGNCID:	12554	Length:	529	Species:	Homo sapiens

Alignment Length:	540	Identity:	167/540 - (30%)
Similarity:	263/540 - (48%)	Gaps:	79/540 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRWLLNSWLLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPI 65
            ::|  .|.:|||...|..|.|....::...|..||:.....:...|...|||||:::     ...
Human     3 VKW--TSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLA-----SSA 60

  Fly    66 KNIIDVETPNIITVMGVYKARI----LENAKKPVLLRY---PR-------------ISLMGLDIT 110
            ..:.|....:.:.: .:|...:    |||.....:.|:   |:             :|:.| |||
Human    61 SILFDPNNSSALKI-EIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFG-DIT 123

  Fly   111 ESLLKE--------PKVQELLKQNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSD 167
            ....|:        .||||     ..||.:..:.....:.. .||.|..|.:...|. :.|:|.:
Human   124 RKFCKDVVSNKKFMKKVQE-----SRFDVIFADAIFPCSEL-LAELFNIPFVYSLSF-SPGYTFE 181

  Fly   168 --LVGTPSPPSYVPHSLLRFGDRMNFWERAQNLGFQIY-EFAYENLINLPRHEALYRKYFPN--- 226
              ..|...||||||..:....|:|.|.||.:|:.:.:| :|.:| :.::.:.:..|.:....
Human   182 KHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFE-IFDMKKWDQFYSEVLGRPTT 245

  Fly   227 -----NKQDFYRMRKDTSLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEA 286
                 .|.|.:         |:.|..:...|.|..||:..|||:|.  |..||||:.:..|::.:
Human   246 LSETMGKADVW---------LIRNSWNFQFPYPLLPNVDFVGGLHC--KPAKPLPKEMEDFVQSS 299

  Fly   287 -EHGVIYFSLGSNLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKPD----NVLISNWLP 346
             |:||:.|||||.::  ::.|.:...|...|..:..:|:|:::.    :|||    |..:..|:|
Human   300 GENGVVVFSLGSMVS--NMTEERANVIASALAQIPQKVLWRFDG----NKPDTLGLNTRLYKWIP 358

  Fly   347 QDDILAHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTAS 411
            |:|:|.|.|..|||||||.....|:||||.|:||||.|.||..|:|..:..|..:.|.:..::::
Human   359 QNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTMSST 423

  Fly   412 LFRSAIERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQY 476
            ...:|::|:.:|||:.|.|..:|....||...||:|||:|:|.|.||||||:||.|..||.:.||
Human   424 DLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQY 488

  Fly   477 HNLDVLATFFSVIGLTVIFV 496
            |:|||:. |..|...||||:
Human   489 HSLDVIG-FLLVCVATVIFI 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	121/373 (32%)
UGT2B7	NP_001065.2	UDPGT	24..525	CDD:278624	159/517 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150449
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3869
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.720