DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302E1 and Ugt2b1

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_690024.1	Gene:	Ugt2b1 / 71773	MGIID:	1919023	Length:	529	Species:	Mus musculus

Alignment Length:	505	Identity:	155/505 - (30%)
Similarity:	242/505 - (47%)	Gaps:	72/505 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SHYAVCFALAKGLAAAGHEVT--------LVSPFPQRKPIKNIIDVETPNIITVMGVYKARI--- 87
            ||:.....:...|...||:||        |:.|..:     :.|:.|         :|.|.:
Mouse    34 SHWINMKIILDELVQRGHDVTVLISSASILIGPSNE-----SSINFE---------IYSAPLSKD 84

  Fly    88 -LENA-------------KKPVLLRY---PRISLMGLDITESLLKEPK-VQELLK--QNRTFDGV 132
             ||.|             |.|....|   .:||....|:.||..|... .:.|:|  |...||.|
Mouse    85 DLEYAFEKWVGNWTYELKKLPFWTSYSKLQKISSEYSDMIESFCKAVVWNKSLMKKLQGSKFDVV 149

  Fly   133 ICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLV--GTPSPPSYVPHSLLRFGDRMNFWERA 195
            :.:..:..... .:|....||: .|.....|:..:..  |.|.||||||..|....|.|.|.||.
Mouse   150 LADALVPCGEL-LSELLKTPLV-YSLRFCPGYKCEKYSGGLPLPPSYVPVVLSELSDHMTFAERV 212

  Fly   196 QN-LGFQIYEFAYENLINLPRHEALYRKYFPN---NKQDFYRMRKDTSLVLLNNHVSISNPRPYS 256
            :| |...:::|.::..     :|..:.:::.:   .......|.....:.|:.....:..|.|:.
Mouse   213 KNMLQVLLFDFWFQTF-----NEKSWNQFYSDVLGRPTTLTEMMGKADIWLVRTFWDLKFPHPFL 272

  Fly   257 PNMIEVGGMHVNRKAPKPLPQNIRKFIEEA-EHGVIYFSLGSNLNSKDLPENKRKAIVETLRGLK 320
            ||...|||:|.  |..||||:.:.:|::.: ||||:.|||||.:  |::.|.|...:...|..:.
Mouse   273 PNFDFVGGLHC--KPAKPLPKEMEEFVQSSGEHGVVVFSLGSMV--KNIKEEKANVVASALAQIP 333

  Fly   321 YRVIWKYEEETFVDKPD----NVLISNWLPQDDILAHEKVIAFITHGGLLSTMESIYHGKPVVGI 381
            .:|:|:::.:    |||    |..:..|:||:|:|.|.|..|||.|||.....|:||||.|:|||
Mouse   334 QKVLWRFDGK----KPDTLGSNTRLYKWIPQNDLLGHPKTKAFIAHGGTNGIYEAIYHGIPIVGI 394

  Fly   382 PFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTERVKVISSQYRDQKETPLE 446
            |.||||..|:......|..:.|.:..::.:...:|::.:.:|||:.|....:|..:.||...||:
Mouse   395 PLFGDQPDNINHIVAKGAAVRVDFDTMSTTDLLTALKTVINDPSYKENAMRLSRIHHDQPMKPLD 459

  Fly   447 RAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGLTVIFV 496
            |||:|:|:|.|:||||:||.|..||.:.|||:|||:. |..|..:.|:|:
Mouse   460 RAVFWIEYVMRNKGAKHLRPALHDLTWFQYHSLDVIG-FLLVCVVAVVFI 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	116/363 (32%)
Ugt2b1	NP_690024.1	egt	8..508	CDD:223071	154/503 (31%)
Ugt2b1	NP_690024.1	UDPGT	24..527	CDD:278624	155/505 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840483
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690