DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and ugt5a1

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001032497.2	Gene:	ugt5a1 / 641479	ZFINID:	ZDB-GENE-051120-60	Length:	525	Species:	Danio rerio

Alignment Length:	526	Identity:	150/526 - (28%)
Similarity:	253/526 - (48%)	Gaps:	51/526 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSP-----FPQRKPIKNI 68
            |..:|.:...::|...|:.  ....||:.....|.:.|...||.||:|.|     ..:..|..:.
Zfish     9 LFSLLCVLSGTYGGKVLVF--PLDGSHWVNMKVLIEELHRKGHNVTVVRPSNSWYIKEESPFYSS 71

  Fly    69 IDVETPNI----ITVMGVYKARILE------------NAKKPVLLRYPRISLMGLDITESLLKEP 117
            |.:  ||.    ....|:...|:||            ..:..:::::..:....|.:.:.:|::.
Zfish    72 ITI--PNTGGFDEEFSGLLINRLLEIKRGGYFVLNRVRLEFEIMMKFKTMHEDMLQMMDRMLEDE 134

  Fly   118 KVQELLKQNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLVG----TPSPPSYV 178
            ||...: |:..||.|:.:..:..... .|..|..||:.     ...||....|    .|||.||:
Zfish   135 KVMNSI-QDAKFDVVLADPAVGGGPI-LAYKFNIPLVF-----NVRWTIQGEGHFAIAPSPLSYI 192

  Fly   179 PHSLLRFGDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKYF-PNNKQDFYRMRKDTSLVL 242
            |...:...|:|:|.:|.:|:...:.......::..|.:.....|:| ||  ..::.:.:|..:.|
Zfish   193 PVPGVELTDKMSFLQRVKNVLIYLISQIQMQIMVEPIYAPFCHKHFGPN--VTYFSLFQDADIWL 255

  Fly   243 LNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEA-EHGVIYFSLGSNLNSKDLPE 306
            :.|..:...|||..||::.:.|...  |..||||.::.||:|.: |||||..|||:.:  ..||:
Zfish   256 MRNDFTFEFPRPTMPNIVYMSGFQC--KPAKPLPNDLEKFVESSGEHGVIVMSLGTLI--AQLPQ 316

  Fly   307 NKRKAIVETLRGLKYRVIWKYEEETFVDKPDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMES 371
            :....|......|..:|||:|.....|...:|.|:..||||:|:|.|.::..|:.|||.....|:
Zfish   317 DMTDDIAAAFAELPQKVIWRYTGPRPVTLGNNTLLVEWLPQNDLLGHPQIKVFVAHGGTNGIQEA 381

  Fly   372 IYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTERVKVISSQ 436
            ||||.|::|:|...||..|:.|.|..|....|..|.|..::|..|::.:..:||:.|.::.:|..
Zfish   382 IYHGVPILGLPLVFDQPDNLFRMEAKGTAKIVDIATLDKTVFLEALKEVLYNPSYRENMQRLSKL 446

  Fly   437 YRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLAT-------FFSVIGLTVI 494
            :.||...||:||::|:|.|.|:|||.:||:....:::|:||::||:.|       |..:||.|:.
Zfish   447 HHDQPLKPLDRAMFWIEFVMRNKGAPHLRTQSFRMSWIEYHSIDVILTLMVTGFVFALMIGYTIK 511

  Fly   495 FVFLLV 500
            :..|.|
Zfish   512 YFCLCV 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	113/355 (32%)
ugt5a1	NP_001032497.2	UDPGT	22..525	CDD:278624	147/513 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584450
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690