Protein Alignment Ugt302E1 and UGT2A2

DIOPT Version :10

• Sequence 1: NP_652625.2
• Gene: Ugt302E1 / 53508
• FlyBaseID: FBgn0040257
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001099147.2
• Gene: UGT2A2 / 574537
• HGNCID: 28183
• Length: 536
• Species: Homo sapiens
• Alignment Length: 510
• Identity: 155/510 - (30%)
• Similarity: 247/510 - (48%)
• Gaps: 46/510 - (9%)

  Fly    10 LLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGL-------AAAGHEVTLVSPFPQRKPIKN 67
            :||....|..|....:::.....::|.....|.:..|       :....||..||  .::..|.:
Human    32 VLIWPTDGSHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVS--YKKSNIDS 94

  Fly    68 IID-------VETPNIITVMGVYK--ARILENAKKPVLLRYPRISLMGLDITESLLKEPKVQELL 123
            :|:       ...|..:|:...||  .::|:.           ...:.:.:.:.:||.||:...|
Human    95 LIEHMIMLWIDHRPTPLTIWAFYKELGKLLDT-----------FFQINIQLCDGVLKNPKLMARL 148

  Fly   124 KQNRTFDGVICE--TFMNDAHYGFAEHFGAP-LITLSSLGATGWTSDLVGTPSPPSYVPHSLLRF 185
             |...||.::.:  |...|.   .|...|.| :.||....|:.........|:|.||||.:|...
Human   149 -QKGGFDVLVADPVTICGDL---VALKLGIPFMYTLRFSPASTVERHCGKIPAPVSYVPAALSEL 209

  Fly   186 GDRMNFWERAQN-LGFQIYEFAYENLINLPRHEALYRKYFPNNKQDFYRMRKDTSLVLLNNHVSI 249
            .|:|.|.||.:| :.:.:.::.:::...  ...:.|.|...........|.| ..:.|:..:...
Human   210 TDQMTFGERIKNTISYSLQDYIFQSYWG--EWNSYYSKILGRPTTLCETMGK-AEIWLIRTYWDF 271

  Fly   250 SNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEA-EHGVIYFSLGSNLNSKDLPENKRKAIV 313
            ..||||.||...|||:|.  |..||||:.:.:||:.: ::||:.|||||.:  |:|.|.|...|.
Human   272 EFPRPYLPNFEFVGGLHC--KPAKPLPKEMEEFIQSSGKNGVVVFSLGSMV--KNLTEEKANLIA 332

  Fly   314 ETLRGLKYRVIWKYEEETFVDKPDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMESIYHGKPV 378
            ..|..:..:|:|:|:.:......:|..:.:|:||:|:|.|.|..|||||||.....|:||||.|:
Human   333 SALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPM 397

  Fly   379 VGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTERVKVISSQYRDQKET 443
            ||:|.|.||..|:|..:..|..:.|....:|:....||:..:.::||:.|....:|..:.||...
Human   398 VGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQPVK 462

  Fly   444 PLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGLTVIFVFL 498
            ||:|||:|:|.|.||||||:||.|..||.:.|||:|||:. |..|...|.||:.:
Human   463 PLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIG-FLLVCVTTAIFLVI 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	Glycosyltransferase_GTB-type	<170..496	CDD:471961	120/327 (37%)
UGT2A2	NP_001099147.2	UDPGT	30..524	CDD:278624	155/510 (30%)