DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and ugt2a2

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001018306.2	Gene:	ugt2a2 / 553952	ZFINID:	ZDB-GENE-080721-21	Length:	534	Species:	Danio rerio

Alignment Length:	551	Identity:	158/551 - (28%)
Similarity:	256/551 - (46%)	Gaps:	93/551 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRWLLNSWLLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLV----SP--- 58
            |:.||....|:::.:|..:...:.|::  ....||:.....:...|....|.||::    ||
Zfish     2 MKCLLKPSPLVLIFIFSFTHAGNVLVL--PGEYSHWQNMRNVVDELLNRNHTVTVLVCSASPTIN 64

  Fly    59 FPQRKPIKNIIDVETPNIITVMGVYKARILENAKKPVL---LRYPRISLMGLDITESLLKEPKVQ 120
            |.|::..:.:: .|.|        ..|:.|:.|.:.::   .::|.        ...|....::.
Zfish    65 FTQQERFQYLV-FEVP--------LSAQELDGASEELIHIWTQHPS--------PNRLQTALQII 112

  Fly   121 ELLKQNRTFDGVICETFM-NDAHYG---------------------FAEHFGAPLITLSSLGATG 163
            |||.:.|.....:|::.: |||...                     .||..|.||: ||...:.|
Zfish   113 ELLGRVRVMHRAMCDSMLRNDALIAQLSALKFDVLFNDPMFMCADLLAEMLGLPLV-LSVRISPG 176

  Fly   164 WTSD-LVG-TPSPPSYVPHSLLRFGDRMNFWERAQNL--------GFQIYEFA-----YENLINL 213
            :..: :.| .|:|||:||.:.....|||.|.||.||:        .|.|..:.     |.:::..
Zfish   177 FCLERMCGQMPAPPSFVPITQTVLTDRMCFMERVQNMIANIVFSVSFYIVAWISLDSYYTDVLGK 241

  Fly   214 PRH--EALYRKYFPNNKQDFYRMRKDTSLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLP 276
            |..  |.:       .|.|.:         |:..:.....|||:.||...|||:|.  |..|||.
Zfish   242 PTTMCETM-------GKADIW---------LIRTYWDFEYPRPFPPNFKFVGGLHC--KPAKPLS 288

  Fly   277 QNIRKFIEEA-EHGVIYFSLGSNLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKPDNVL 340
            :.:.:|::.: :|||:.|||||.:  |:|...:...|...|..:..:|:|:|..:|......|..
Zfish   289 KEMEEFVQSSGDHGVVVFSLGSMI--KNLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTK 351

  Fly   341 ISNWLPQDDILAHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKY 405
            |.:|:||:|:|.|.|..|||||||.....|:||||.|:||:|.|.||..|:...:..|..:.:..
Zfish   352 IYDWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDI 416

  Fly   406 AQLTASLFRSAIERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQD 470
            ..|.:.....|::.:.::||:.|.:..:|..:.||...||::||||:|.|.|:||||:||....:
Zfish   417 NTLESKDLVDALKTVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHE 481

  Fly   471 LNFIQYHNLDVLATFFSVIGLTVIFVFLLVR 501
            |::.|||.|||.|...|:..|   ..||.|:
Zfish   482 LSWYQYHCLDVAAFLLSIAAL---ITFLWVK 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	120/389 (31%)
ugt2a2	NP_001018306.2	UDPGT	23..521	CDD:278624	153/530 (29%)
ugt2a2	NP_001018306.2	egt	<256..487	CDD:223071	85/234 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.860