Protein Alignment Ugt302E1 and UGT1A3

DIOPT Version :10

• Sequence 1: NP_652625.2
• Gene: Ugt302E1 / 53508
• FlyBaseID: FBgn0040257
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_061966.1
• Gene: UGT1A3 / 54659
• HGNCID: 12535
• Length: 534
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 164/523 - (31%)
• Similarity: 253/523 - (48%)
• Gaps: 56/523 - (10%)

  Fly     3 WLLNSWLLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPIK- 66
            ||... |||:|::  |.|..|..::......||:.....:.:.|.|.||:..:::| .....||
Human    11 WLATG-LLLLLSV--QPWAESGKVLVVPIDGSHWLSMREVLRELHARGHQAVVLTP-EVNMHIKE 71

  Fly    67 -NIIDVETPNIITVMGVYKARIL---------ENAKKPVLLRYPRISLMGL----DITESLLKEP 117
             |...:.|..|......:...:|         |:..|........::.|.|    ...|.|..|.
Human    72 ENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNMSLVYHRSCVELLHNEA 136

  Fly   118 KVQELLKQNRT-FDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLVGT--PSPPSYVP 179
            .::.|   |.| ||.|:.:. :|......|::...|  |:..|.......|..||  |:|.||:|
Human   137 LIRHL---NATSFDVVLTDP-VNLCAAVLAKYLSIP--TVFFLRNIPCDLDFKGTQCPNPSSYIP 195

  Fly   180 HSLLRFGDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKYFPNNKQDFYRMRKDTSLVLLN 244
            ..|....|.|.|.:|.:|:   :|..|...:.:     |....|.....:.|.|   :.|:|.:.
Human   196 RLLTTNSDHMTFMQRVKNM---LYPLALSYICH-----AFSAPYASLASELFQR---EVSVVDIL 249

  Fly   245 NHVSI---------SNPRPYSPNMIEVGGMH-VNRKAPKPLPQNIRKFIE-EAEHGVIYFSLGSN 298
            :|.|:         ..|||..|||:.:||:: .||   |||.|....:|. ..|||::.|||||.
Human   250 SHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANR---KPLSQEFEAYINASGEHGIVVFSLGSM 311

  Fly   299 LNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKPDNVLISNWLPQDDILAHEKVIAFITHG 363
            ::  ::||.|..||.:.|..:...|:|:|......:..:|.::..||||:|:|.|....|||||.
Human   312 VS--EIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHA 374

  Fly   364 GLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTE 428
            |.....|||.:|.|:|.:|.||||..|..|.|..|.|:|:...::|:....:|::.:.:|.|:.|
Human   375 GSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKE 439

  Fly   429 RVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGLTV 493
            .:..:||.::|:...||:.||:|||.|.|||||.:||.|..||.:.|||:|||:....:|: |||
Human   440 NIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVV-LTV 503

  Fly   494 IFV 496
            .|:
Human   504 AFI 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	Glycosyltransferase_GTB-type	<170..496	CDD:471961	122/338 (36%)
UGT1A3	NP_061966.1	UDPGT	29..525	CDD:278624	155/502 (31%)