Protein Alignment Ugt302E1 and UGT1A1

DIOPT Version :10

• Sequence 1: NP_652625.2
• Gene: Ugt302E1 / 53508
• FlyBaseID: FBgn0040257
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_000454.1
• Gene: UGT1A1 / 54658
• HGNCID: 12530
• Length: 533
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 156/533 - (29%)
• Similarity: 252/533 - (47%)
• Gaps: 89/533 - (16%)

  Fly    11 LILALFGQSWGYSYLMISHTASK--------SHYAVCFALAKGLAAAGHEVTLVSP--------- 58
            |:|.:.|.       ::|| |.|        ||:.......:.|...|||:.:::|
Human    15 LLLCVLGP-------VVSH-AGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVLAPDASLYIRDG 71

  Fly    59 -------FP---QRKPIK--------NIIDVETPNIITVMGVYKARILENAKKPVLLRYPRISLM 105
                   :|   ||:.:|        |:.:.::         :..|:::..||     ..:.|.|
Human    72 AFYTLKTYPVPFQREDVKESFVSLGHNVFENDS---------FLQRVIKTYKK-----IKKDSAM 122

  Fly   106 GLDITESLLKEPKVQELLKQNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLVG 170
            .|.....||...::...|.:: :||.::.:.|:..:.. .|::...|  |:..|.|...:.:...
Human   123 LLSGCSHLLHNKELMASLAES-SFDVMLTDPFLPCSPI-VAQYLSLP--TVFFLHALPCSLEFEA 183

  Fly   171 T--PSPPSYVPHSLLRFGDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKY------FPNN 227
            |  |:|.||||..|....|.|.|.:|.:|:   :..|:...|.     :.:|..|      |...
Human   184 TQCPNPFSYVPRPLSSHSDHMTFLQRVKNM---LIAFSQNFLC-----DVVYSPYATLASEFLQR 240

  Fly   228 KQDFYRMRKDTSLVLLNNHVSISNPRPYSPNMIEVGG---MHVNRKAPKPLPQNIRKFIE-EAEH 288
            :.....:....|:.|..:......|||..|||:.|||   :|.|     ||.|....:|. ..||
Human   241 EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQN-----PLSQEFEAYINASGEH 300

  Fly   289 GVIYFSLGSNLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKPDNVLISNWLPQDDILAH 353
            |::.|||||.::  ::||.|..||.:.|..:...|:|:|......:..:|.::..||||:|:|.|
Human   301 GIVVFSLGSMVS--EIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH 363

  Fly   354 EKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIE 418
            ....|||||.|.....|||.:|.|:|.:|.||||..|..|.|..|.|:|:...::|:....:|::
Human   364 PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALK 428

  Fly   419 RITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLA 483
            .:.:|.|:.|.:..:||.::|:...||:.||:|||.|.|||||.:||.|..||.:.|||:|||:.
Human   429 AVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIG 493

  Fly   484 TFFSVIGLTVIFV 496
            ...:|: |||.|:
Human   494 FLLAVV-LTVAFI 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	Glycosyltransferase_GTB-type	<170..496	CDD:471961	119/337 (35%)
UGT1A1	NP_000454.1	UDPGT	28..524	CDD:278624	150/512 (29%)