Protein Alignment Ugt302E1 and UGT1A9

DIOPT Version :10

• Sequence 1: NP_652625.2
• Gene: Ugt302E1 / 53508
• FlyBaseID: FBgn0040257
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_066307.1
• Gene: UGT1A9 / 54600
• HGNCID: 12541
• Length: 530
• Species: Homo sapiens
• Alignment Length: 495
• Identity: 160/495 - (32%)
• Similarity: 246/495 - (49%)
• Gaps: 60/495 - (12%)

  Fly    34 SHYAVCFALAKGLAAAGHEVTLVSPFPQRKPIKNIIDVETPNIITVMGVYKARILE-------NA 91
            ||:....::.:.|...||||.:|.|....:..:::    ...:.|....|....|:       :|
Human    36 SHWFTMRSVVEKLILRGHEVVVVMPEVSWQLGRSL----NCTVKTYSTSYTLEDLDREFKAFAHA 96

  Fly    92 KKPVLLRYPRISLMGL--DITE-------SLLKEPKVQELLKQNRTFDGVICETFMNDAHYGF-- 145
            :....:|.....|||.  ||.:       ||.|:.|:.|.||:: :||.|..:.|.|   .|.
Human    97 QWKAQVRSIYSLLMGSYNDIFDLFFSNCRSLFKDKKLVEYLKES-SFDAVFLDPFDN---CGLIV 157

  Fly   146 AEHFGAPLITLSSLGATGWTSDLVGTPSPPSYVPHSLLRFGDRMNFWERAQNLGFQIYEFAYENL 210
            |::|..|.:..:......:..:....|:|.||||..||.|.|.|.|.||.:|           ::
Human   158 AKYFSLPSVVFARGILCHYLEEGAQCPAPLSYVPRILLGFSDAMTFKERVRN-----------HI 211

  Fly   211 INLPRHEALYRKYFPN-------------NKQDFYRMRKDTSLVLLNNHVSISNPRPYSPNMIEV 262
            ::|..| .|..::|.|             .:.|.|   ..||:.||.....:..|:|..||||.:
Human   212 MHLEEH-LLCHRFFKNALEIASEILQTPVTEYDLY---SHTSIWLLRTDFVLDYPKPVMPNMIFI 272

  Fly   263 GGMHVNRKAPKPLPQNIRKFIE-EAEHGVIYFSLGSNLNSKDLPENKRKAIVETLRGLKYRVIWK 326
            ||  :|....||||.....:|. ..|||::.|||||.::  ::||.|..||.:.|..:...|:|:
Human   273 GG--INCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVS--EIPEKKAMAIADALGKIPQTVLWR 333

  Fly   327 YEEETFVDKPDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNM 391
            |......:..:|.::..||||:|:|.|....|||||.|.....|||.:|.|:|.:|.||||..|.
Human   334 YTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNA 398

  Fly   392 ARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVT 456
            .|.|..|.|:|:...::|:....:|::.:.:|.|:.|.:..:||.::|:...||:.||:|||.|.
Human   399 KRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVM 463

  Fly   457 RHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGLTVIFV 496
            |||||.:||.|..||.:.|||:|||:....:|: |||.|:
Human   464 RHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVV-LTVAFI 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	Glycosyltransferase_GTB-type	<170..496	CDD:471961	124/339 (37%)
UGT1A9	NP_066307.1	UDPGT	26..521	CDD:278624	160/495 (32%)