Protein Alignment Ugt302E1 and UGT1A5

DIOPT Version :9

• Sequence 1: NP_652625.2
• Gene: Ugt302E1 / 53508
• FlyBaseID: FBgn0040257
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 162/522 - (31%)
• Similarity: 259/522 - (49%)
• Gaps: 57/522 - (10%)

  Fly     5 LNSWLLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPIK--N 67
            |.:.|||:|::  |.|..|..::......||:.......:.|.|.||:|.::: ......||  |
Human    12 LATGLLLLLSV--QPWAESGKVLVVPTDGSHWLSMREALRDLHARGHQVVVLT-LEVNMYIKEEN 73

  Fly    68 IIDVETPNIITVMGVYKARILENAK-----KPVLLRYPR----ISLMGLDI----TESLLKEPKV 119
            ...:.|..|......:...:|.:.:     :.:|:::.|    ::.|.|.|    .|.|..|..:
Human    74 FFTLTTYAISWTQDEFDRLLLGHTQSFFETEHLLMKFSRRMAIMNNMSLIIHRSCVELLHNEALI 138

  Fly   120 QELLKQNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLVGT--PSPPSYVPHSL 182
            :.|  ...:||.|:.:.|...|.. .|::...|.:..  |.......|..||  |:|.||:|..|
Human   139 RHL--HATSFDVVLTDPFHLCAAV-LAKYLSIPAVFF--LRNIPCDLDFKGTQCPNPSSYIPRLL 198

  Fly   183 LRFGDRMNFWERAQNLGFQIYEFAYENL---INLPRHEALYRKYFPNNKQDFYRMRKDTSLVLLN 244
            ....|.|.|.:|.:|:   :|..|...|   ::.| :.:|..:.|          :::.|:|.|.
Human   199 TTNSDHMTFLQRVKNM---LYPLALSYLCHAVSAP-YASLASELF----------QREVSVVDLV 249

  Fly   245 NHVSI---------SNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIE-EAEHGVIYFSLGSNL 299
            :|.|:         ..|||..|||:.:||  :|....|||.|....:|. ..|||::.|||||.:
Human   250 SHASVWLFRGDFVMDYPRPIMPNMVFIGG--INCANGKPLSQEFEAYINASGEHGIVVFSLGSMV 312

  Fly   300 NSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKPDNVLISNWLPQDDILAHEKVIAFITHGG 364
            :  ::||.|..||.:.|..:...|:|:|......:..:|.::..||||:|:|.|....|||||.|
Human   313 S--EIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAG 375

  Fly   365 LLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTER 429
            .....|||.:|.|:|.:|.||||..|..|.|..|.|:|:...::|:....:|::.:.:|.|:.|.
Human   376 SHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKEN 440

  Fly   430 VKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGLTVI 494
            :..:||.::|:...||:.||:|||.|.|||||.:||.|..||.:.|||:|||:....:|: |||.
Human   441 IMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVV-LTVA 504

  Fly   495 FV 496
            |:
Human   505 FI 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	118/364 (32%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	154/503 (31%)
		egt	<262..508	CDD:223071	99/250 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150604
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.790