Protein Alignment Ugt302E1 and UGT1A6

DIOPT Version :10

• Sequence 1: NP_652625.2
• Gene: Ugt302E1 / 53508
• FlyBaseID: FBgn0040257
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001063.2
• Gene: UGT1A6 / 54578
• HGNCID: 12538
• Length: 532
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 163/551 - (29%)
• Similarity: 247/551 - (44%)
• Gaps: 102/551 - (18%)

  Fly     1 MRWLLNSWL-----LLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSP-- 58
            |..||.|:.     :..|||:|...|...|::....  ||:.....:.:.|:..|||:.:|.|
Human     1 MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDG--SHWLSMKDIVEVLSDRGHEIVVVVPEV 63

  Fly    59 --------------FP---QRKPIKN-----------------IIDVETPNIITVMGVYKARILE 89
                          :|   .::.:||                 ....|..|.:.|:|:|    ..
Human    64 NLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIGLY----FI 124

  Fly    90 NAKKPVLLRYPRISLMGLDITESLLKEPKVQELLKQNRTFDGVICETFMNDAHYGFAEHFGAPLI 154
            |.:          ||:....|.:..||.|...|........|||           .||:.|.|.:
Human   125 NCQ----------SLLQDRDTLNFFKESKFDALFTDPALPCGVI-----------LAEYLGLPSV 168

  Fly   155 TLSSLGATGWTSDLVGT----PSPPSYVPHSLLRFGDRMNFWERAQNLGFQIYEFAYENLINLPR 215
            .|    ..|:...|..|    |.|.||:|....:|.|.|.|.:|..|.           |:||..
Human   169 YL----FRGFPCSLEHTFSRSPDPVSYIPRCYTKFSDHMTFSQRVANF-----------LVNLLE 218

  Fly   216 HEALYRKYFPNNKQDFYRMRKDTSLVLLNNHVSI---------SNPRPYSPNMIEVGGMHVNRKA 271
            ....|..:....:.....:::|..::.|...||:         ..|||..|||:.:||  :|.|.
Human   219 PYLFYCLFSKYEELASAVLKRDVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGG--INCKK 281

  Fly   272 PKPLPQNIRKFIE-EAEHGVIYFSLGSNLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDK 335
            .|.|.|....:|. ..|||::.|||||.::  ::||.|..||.:.|..:...|:|:|......:.
Human   282 RKDLSQEFEAYINASGEHGIVVFSLGSMVS--EIPEKKAMAIADALGKIPQTVLWRYTGTRPSNL 344

  Fly   336 PDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYG 400
            .:|.::..||||:|:|.|....|||||.|.....|||.:|.|:|.:|.||||..|..|.|..|.|
Human   345 ANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAG 409

  Fly   401 ITVKYAQLTASLFRSAIERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLR 465
            :|:...::|:....:|::.:.:|.|:.|.:..:||.::|:...||:.||:|||.|.|||||.:||
Human   410 VTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR 474

  Fly   466 SACQDLNFIQYHNLDVLATFFSVIGLTVIFV 496
            .|..||.:.|||:|||:....:|: |||.|:
Human   475 PAAHDLTWYQYHSLDVIGFLLAVV-LTVAFI 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	Glycosyltransferase_GTB-type	<170..496	CDD:471961	118/339 (35%)
UGT1A6	NP_001063.2	UDPGT	27..523	CDD:278624	154/525 (29%)