Protein Alignment Ugt302E1 and UGT1A8

DIOPT Version :9

• Sequence 1: NP_652625.2
• Gene: Ugt302E1 / 53508
• FlyBaseID: FBgn0040257
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_061949.3
• Gene: UGT1A8 / 54576
• HGNCID: 12540
• Length: 530
• Species: Homo sapiens
• Alignment Length: 497
• Identity: 160/497 - (32%)
• Similarity: 247/497 - (49%)
• Gaps: 64/497 - (12%)

  Fly    34 SHYAVCFALAKGLAAAGHEVTLVSPFPQRKPIKNIIDVETPNIITVMGVYKARILE-------NA 91
            ||:....::.:.|...||||.:|.|....:..|::    ...:.|....|....|:       :|
Human    36 SHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGKSL----NCTVKTYSTSYTLEDLDREFMDFADA 96

  Fly    92 KKPVLLRYPRISLMGLDIT-------------ESLLKEPKVQELLKQNRTFDGVICETFMNDAHY 143
            :....:|    ||..|.::             .||..:.|:.|.||:: :||.|..:.|  || .
Human    97 QWKAQVR----SLFSLFLSSSNGFFNLFFSHCRSLFNDRKLVEYLKES-SFDAVFLDPF--DA-C 153

  Fly   144 GF--AEHFGAPLITLSSLGATGWTSDLVGTPSPPSYVPHSLLRFGDRMNFWERAQNLGFQIYEFA 206
            |.  |::|..|.:..:...|..:..:....|:|.||||..||.|.|.|.|.||.:|
Human   154 GLIVAKYFSLPSVVFARGIACHYLEEGAQCPAPLSYVPRILLGFSDAMTFKERVRN--------- 209

  Fly   207 YENLINLPRHEALYRKYFPNNKQDF-----------YRMRKDTSLVLLNNHVSISNPRPYSPNMI 260
              ::::|..|  |:.:||..|..:.           |.:...||:.||.....:..|:|..||||
Human   210 --HIMHLEEH--LFCQYFSKNALEIASEILQTPVTAYDLYSHTSIWLLRTDFVLDYPKPVMPNMI 270

  Fly   261 EVGGMHVNRKAPKPLPQNIRKFIE-EAEHGVIYFSLGSNLNSKDLPENKRKAIVETLRGLKYRVI 324
            .:||  :|....||||.....:|. ..|||::.|||||.::  ::||.|..||.:.|..:...|:
Human   271 FIGG--INCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVS--EIPEKKAMAIADALGKIPQTVL 331

  Fly   325 WKYEEETFVDKPDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFM 389
            |:|......:..:|.::..||||:|:|.|....|||||.|.....|||.:|.|:|.:|.||||..
Human   332 WRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMD 396

  Fly   390 NMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEH 454
            |..|.|..|.|:|:...::|:....:|::.:.:|.|:.|.:..:||.::|:...||:.||:|||.
Human   397 NAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEF 461

  Fly   455 VTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGLTVIFV 496
            |.|||||.:||.|..||.:.|||:|||:....:|: |||.|:
Human   462 VMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVV-LTVAFI 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	124/363 (34%)
UGT1A8	NP_061949.3	UDPGT	26..521	CDD:278624	160/497 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150375
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690