Protein Alignment Ugt302E1 and UGT1A10

DIOPT Version :10

• Sequence 1: NP_652625.2
• Gene: Ugt302E1 / 53508
• FlyBaseID: FBgn0040257
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_061948.1
• Gene: UGT1A10 / 54575
• HGNCID: 12531
• Length: 530
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 153/494 - (30%)
• Similarity: 241/494 - (48%)
• Gaps: 58/494 - (11%)

  Fly    34 SHYAVCFALAKGLAAAGHEVTLVSPFPQRKPIKNIIDVETPNIITVMGVYKARILENAKKPVLL- 97
            ||:....::.:.|...||||.:|.|       :....:|.....||.....:..||:..:..::
Human    36 SHWFTMQSVVEKLILRGHEVVVVMP-------EVSWQLERSLNCTVKTYSTSYTLEDQNREFMVF 93

  Fly    98 -----RYPRISLMGLDIT-------------ESLLKEPKVQELLKQNRTFDGVICETFMNDAHYG 144
                 :....|:..|.::             .||..:.|:.|.||:: :||.|..:.| :.....
Human    94 AHAQWKAQAQSIFSLLMSSSSGFLDLFFSHCRSLFNDRKLVEYLKES-SFDAVFLDPF-DTCGLI 156

  Fly   145 FAEHFGAPLITLSSLGATGWTSDLVGTPSPPSYVPHSLLRFGDRMNFWERAQNLGFQIYEFAYEN 209
            .|::|..|.:..:.........:....|:|.||||:.||.|.|.|.|.||..|           :
Human   157 VAKYFSLPSVVFTRGIFCHHLEEGAQCPAPLSYVPNDLLGFSDAMTFKERVWN-----------H 210

  Fly   210 LINLPRHEALYRKYFPNNKQDF-----------YRMRKDTSLVLLNNHVSISNPRPYSPNMIEVG 263
            :::|..|  |:.:|...|..:.           |.:...||:.||.....:..|:|..||||.:|
Human   211 IVHLEDH--LFCQYLFRNALEIASEILQTPVTAYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIG 273

  Fly   264 GMHVNRKAPKPLPQNIRKFIE-EAEHGVIYFSLGSNLNSKDLPENKRKAIVETLRGLKYRVIWKY 327
            |  :|....||||.....:|. ..|||::.|||||.::  ::||.|..||.:.|..:...|:|:|
Human   274 G--INCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVS--EIPEKKAMAIADALGKIPQTVLWRY 334

  Fly   328 EEETFVDKPDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMA 392
            ......:..:|.::..||||:|:|.|....|||||.|.....|||.:|.|:|.:|.||||..|..
Human   335 TGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAK 399

  Fly   393 RAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTR 457
            |.|..|.|:|:...::|:....:|::.:.:|.|:.|.:..:||.::|:...||:.||:|||.|.|
Human   400 RMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMR 464

  Fly   458 HKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGLTVIFV 496
            ||||.:||.|..||.:.|||:|||:....:|: |||.|:
Human   465 HKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVV-LTVAFI 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	Glycosyltransferase_GTB-type	<170..496	CDD:471961	123/337 (36%)
UGT1A10	NP_061948.1	UDPGT	26..521	CDD:278624	153/494 (31%)