DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302E1 and Ugt35E1

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	199/536 - (37%)
Similarity:	306/536 - (57%)	Gaps:	30/536 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLNSWLLLILALF-GQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPIKN 67
            |.:....||:.|| |..:|...|.:....|.|||.......|.||:.|||:|.|||||..:|:||
  Fly     2 LASGLFYLIILLFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSVSPFPSEEPVKN 66

  Fly    68 IIDVETPNIITVMGVYKARILENAKKP--VLLRYPRISLMGLDITESLLKEPKV-QELLKQNRT- 128
            |.|:..|.::....    .:|:....|  ....:...:....:||:.:.....| :|:|:..:.
  Fly    67 IYDIYVPEVLNSFD----ELLKQMTTPKNTWEFFDATNEFVYNITKDVFNNDGVRREILRPGKAQ 127

  Fly   129 FDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLVGTPSPPSYV--PHSLL----RFGD 187
            ||.:|.:.:..||.|..|.:|.||:|.|:..|......::||.|||.||:  |.|.|    .||.
  Fly   128 FDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSYLQSPSSYLYNLDTFGG 192

  Fly   188 RMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKYFPN--NKQDFYRMRKDTSLVLLNNHVSIS 250
            |:..........|. :.:.||.     :|||||:||||.  ..:....:.:|.:|||:|.|.::.
  Fly   193 RVAHVVEVAISWFN-WHWRYEQ-----KHEALYKKYFPKIAETKPLSEISQDIALVLVNQHFTLG 251

  Fly   251 NPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIE-EAEHGVIYFSLGSNLNSKDLPENKRKAIVE 314
            .||||.||:|||||||::.: ||.|.|::..||: ..||||||||||:|:.:|::.:::::.::|
  Fly   252 PPRPYVPNVIEVGGMHIDEQ-PKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIE 315

  Fly   315 TLRGLKYRVIWKYEEETFVDKPDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMESIYHGKPVV 379
            ....|..||:||:|:|...|.|.|||:..||||.|:|||.||..||||||:.||:|||::|||::
  Fly   316 AFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPML 380

  Fly   380 GIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTERVKVISSQYRDQKETP 444
            |:|||.|||.|:...::.|:.:::.|..:|:...::.|.::.::..|....::..::||||...|
  Fly   381 GLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQPMKP 445

  Fly   445 LERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGLTVIFVFLLVRFLV----- 504
            ||.||:|..:|.|||||.::|.|.:.|:|..:|:||||.|...||.|.:|.:.|::.|.|
  Fly   446 LETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVCKISK 510

  Fly   505 TIVNGFLYKPSSKLKI 520
            .|....:.|...|.|:
  Fly   511 NISTRLVVKKQRKQKV 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	144/360 (40%)
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	174/465 (37%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	177/461 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445623
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.800