DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302E1 and Ugt304A1

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	169/535 - (31%)
Similarity:	279/535 - (52%)	Gaps:	32/535 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RWLLNSWLLLILALFGQSWGYS--YLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKP 64
            ||||..:.|:..::   .|..|  .|:|:...|.|...:.....:.|...||::|::..:
  Fly     6 RWLLPMFWLISNSI---CWIRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVIHAY----- 62

  Fly    65 IKNII-DVETPNIITVMGVYKARILENAKKPVLL-----RYPRISLMG---LDITESLLKEPKVQ 120
             |:.: .:|....|.:.  |...:....::.|.:     ::..||.|.   .:.|.::|...:|:
  Fly    63 -KHCMHKIEDVTFIRIW--YNNNVFLEFEESVGIASANNKWEEISSMSSLMANATLNVLNNVEVR 124

  Fly   121 ELLKQNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLVGTPSPPSYVPHSLLRF 185
            .|:|...|||.|:.|...:|..||.|.||.|.||.:.:..|....::|||..:.....|....|.
  Fly   125 ALMKSRITFDAVVLEAGYSDVLYGMAAHFSAQLIGICTCVADWNINNLVGFSTSTLTEPIMPFRA 189

  Fly   186 GDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKYFPNNKQDFYRMRKDTSLVLLNNHVSIS 250
            ....|.|:|..|..:...|:...||:.||:...::..:|.:.::.|:.:|:|.:|:|||.|.|:.
  Fly   190 KYVKNVWDRIYNWLYTTEEWLLINLVFLPKQRLIHDHFFGHLEKSFHEIRQDFALMLLNQHFSLF 254

  Fly   251 NPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEAEHGVIYFSLGSNLNSKDLPENKRKAIVET 315
            ..||..|.|:||.|:|:.::.|: ||.:::.||:|||||||.||||...:|||||...::.:|||
  Fly   255 RARPNVPGMVEVAGLHIPKEDPQ-LPSDLQVFIDEAEHGVILFSLGLEQDSKDLPRKTQEILVET 318

  Fly   316 LRGLKYRVIWKYEEETFVDKPDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMESIYHGKPVVG 380
            .:.:..|||||::.|:.:....::..|..|||..||||..|..||:|.|::|.:|:.|:.|||:|
  Fly   319 FKSVPQRVIWKFDGESTMSLGTDIYHSKLLPQQAILAHPNVKLFISHCGMMSVIEAAYYAKPVLG 383

  Fly   381 IPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTERVKVISSQYRDQKETPL 445
            :|.|.|||.|:...::.|..:.:....||....:.||..:.::|.:.|....||.::|||...||
  Fly   384 LPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAIHSMINEPEYRESALAISQRFRDQPIHPL 448

  Fly   446 ERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGLTVIFVFLL-------VRFL 503
            :.|:||.|::.|:|||.:::.:...|....|::||......|.:.|.|..|||:       :..|
  Fly   449 DAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDNFIMVGSRLSLVVALVFLVLSKSRRWLNHL 513

  Fly   504 VTIVNGFLYKPSSKL 518
            .|....||  |:..|
  Fly   514 STSAKSFL--PTKHL 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	129/349 (37%)
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	152/483 (31%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	132/411 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445620
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	9.800