DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and Ugt8

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_062149.1	Gene:	Ugt8 / 50555	RGDID:	3938	Length:	541	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	157/548 - (28%)
Similarity:	262/548 - (47%)	Gaps:	85/548 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WLLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPIKNIIDVE 72
            :.:|:.:..|.:.....:::.....:||..:...||..|...||.
  Rat     7 YFMLLWSAVGIARAAKIIIVPPIMFESHLYIFKTLASALHERGHH-------------------- 51

  Fly    73 TPNIITVMGVYKARILENAKKPVLLRYP----------------------RISLMGL-DITESLL 114
                 ||..:.:.|.::.:....|.|||                      |::.:.| ||.:...
  Rat    52 -----TVFLLSEGRDIDPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAVELVDILDHYT 111

  Fly   115 K--------EPKVQELLKQNRTFDGVICETFMNDAHYGF--AEHFGAPLITLSSLGATG-WTSDL 168
            |        :..:|.|.|:.  ||.::.:.  ||. .||  |...|......|    || |....
  Rat   112 KNCDMMVGNQALIQGLKKEK--FDLLLVDP--NDM-CGFVIAHLLGVKYAVFS----TGLWYPAE 167

  Fly   169 VGTPSPPSYVP--HSLLRFGDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKYFPNNKQDF 231
            ||.|:|.:|||  :|||.  |||||.||.:|.|..:......:.:.||::|.:.:||.....:..
  Rat   168 VGAPAPLAYVPEFNSLLT--DRMNFLERMKNTGVYLISRMGVSFLVLPKYERIMQKYNLLPAKSM 230

  Fly   232 YRMRKDTSLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEA-EHGVIYFSL 295
            |.:...:||.:|...|::..|||..||::.|||  :..|...|||::::::::.| |||.:..|.
  Rat   231 YDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGG--ILTKPASPLPEDLQRWVDGAQEHGFVLVSF 293

  Fly   296 GSNLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKPDNVLISNWLPQDDILAHEKVIAFI 360
            |:.:  |.|.|:....:...|..|..:|||::......:..:|..:..||||:|:|.|..:.||:
  Rat   294 GAGV--KYLSEDIANKLAGALGRLPQKVIWRFSGTKPKNLGNNTKLIEWLPQNDLLGHSNIRAFL 356

  Fly   361 THGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPS 425
            :||||.|..|::|||.||||||.|||.:..|.|.:..|.||.:::..:|......|:.::.::||
  Rat   357 SHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKVINNPS 421

  Fly   426 FTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIG 490
            :.:|.:.:|..::||...|:.|..||::::.||.||.:||||...::|.||..||:  .|..::|
  Rat   422 YRQRAQKLSEIHKDQPGHPVNRTTYWIDYILRHDGAHHLRSAVHQISFCQYFLLDI--AFVLLLG 484

  Fly   491 LTVIFVFLLVRFLVTIVNGFLYKPSSKL 518
            ...::      |:|:.|..|:|:....|
  Rat   485 AVALY------FIVSYVTKFIYRKVKSL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	120/363 (33%)
Ugt8	NP_062149.1	egt	8..490	CDD:223071	151/529 (29%)
Ugt8	NP_062149.1	UDPGT	21..502	CDD:278624	154/528 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344192
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.740