DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302E1 and Ugt37A3

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	184/537 - (34%)
Similarity:	276/537 - (51%)	Gaps:	38/537 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LNSWLLLILAL---FGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPI- 65
            :..:|||.:|:   .|.|.|.:.|.:..:.|.||..:..:.||.||..||.||:|:..   ||:
  Fly     5 VEKFLLLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVL---KPVV 66

  Fly    66 --KNIIDVETP-------NIITVMGVYKARILENAKKPVLLRYPRISLMGLDITESLLKEPKVQE 121
              |||..::.|       .:...:|........|....:|....::..|.....|:|:.: :|::
  Fly    67 NHKNITVIQVPLSKEEAQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETLMND-RVRD 130

  Fly   122 L-LKQNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLVGTPSPPSYVPHSLLRF 185
            | |.:...||.||...||||...|||....||:|.|:::......:.|:|.|...||...|....
  Fly   131 LYLNRGNKFDLVISGYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGNPLEVSYAGISNPAE 195

  Fly   186 GDRMNFWER-----AQNLGFQIYEFAYENLINLPRHEALYRKYFPNNKQ--DFYRMRKDTSLVLL 243
            |.:...::|     .|:|||.::....|.     |:...|::.:.|:.:  ::..|.|:||||..
  Fly   196 GSKAVTFQRRLSSYMQSLGFGVFSHLSER-----RNRNWYKEVYGNDPKMPEYSEMLKNTSLVFF 255

  Fly   244 NNHVSISNP-RPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEAEHGVIYFSLGSNLNSKDLPEN 307
            ::|.:...| ||..|:.||:||:.:..| |.||||||.:|:..|..|.|..|||||:..|.|..:
  Fly   256 SSHAASEGPIRPNVPSAIEIGGIQIKDK-PDPLPQNIAEFLGNATDGAILLSLGSNVQGKHLNPD 319

  Fly   308 KRKAIVETLRGLKYRVIWKYE-EETFVDKPDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMES 371
            ....:...|..||.|||||:| :|....|..|:|.|.||||||||||..:..||.|.|.....||
  Fly   320 TVAKMFNVLSKLKERVIWKWEDQENTPGKSANILYSKWLPQDDILAHPNIKLFINHAGKGGITES 384

  Fly   372 IYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTERVKVISSQ 436
            .|||||::.:|.|.||..|.....:.|:|:|:....|....|:.||..|.|:|.:.||||..|:.
  Fly   385 QYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAERVKSFSTL 449

  Fly   437 YRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGLTVIFVFLLVR 501
            |||:..|..|..:||.|:|.||.||.:|:|....::||..:|:|:....|.::    :.|.:|::
  Fly   450 YRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDICFLIFVIL----VSVLVLIK 510

  Fly   502 FLVT-IVNGFLYKPSSK 517
            |||. |...|:.||..:
  Fly   511 FLVQFIYRRFISKPKKE 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	136/359 (38%)
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	172/494 (35%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	175/502 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445788
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	9.000