DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and ugt1ab

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_998587.2	Gene:	ugt1ab / 406731	ZFINID:	ZDB-GENE-040426-2762	Length:	536	Species:	Danio rerio

Alignment Length:	540	Identity:	157/540 - (29%)
Similarity:	254/540 - (47%)	Gaps:	99/540 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPIKNIIDVET 73
            |...|.||......:..::......||:.....|.:.:::.|||:.::.|             ||
Zfish    22 LFAFLCLFSSESVQAGKVLVMPVDGSHWLSMKILVEEMSSRGHEMVVLVP-------------ET 73

  Fly    74 PNIITVMGVYKARI-------------LENAKKPVLLRYPR-ISLMG------------LDITES 112
            ..:|...|.:..:.             :::.:|..:.:.|| |.::|            :...|.
Zfish    74 SILIGKSGNFTTKSFRVPYSFDELNAHVDHIRKTAIEKAPRFIDIVGALGNLIQFTNMQVKACEG 138

  Fly   113 LL-KEPKVQELLKQNRTFDGVICETFMNDAHYGFAEHFGAPLI--------TLSSLGATGWTSDL 168
            || .||.::.|  ::..||.::.:.|:..... .|::|..|.:        .|....|.
Zfish   139 LLYDEPLMKSL--RDMKFDALLTDPFLPCGSV-IADYFSIPAVYFLRGIPCRLDEAAAQ------ 194

  Fly   169 VGTPSPPSYVPHSLLRFGDRMNFWERAQNLGFQIYE-------FAYENLINLPRHEALYRKYFPN 226
              .|||||::|.....:.|:|.|.:|..|....::|       ||        ..:.|..:|
Zfish   195 --CPSPPSFIPRFFTGYTDKMTFPQRMINTFMTVFEKYLCHQLFA--------SFDELATRY--- 246

  Fly   227 NKQDFYRMRKDTSLVLLNNH---------VSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKF 282
                   ::||||...|..|         .|...|:|..|||:::||::..::|  ||.:.:.:|
Zfish   247 -------LKKDTSYAELLGHGAVWLLRYDFSFEYPKPQMPNMVQIGGINCAKRA--PLTKELEEF 302

  Fly   283 IE-EAEHGVIYFSLGSNLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKPDNVLISNWLP 346
            :. ..|||.:.|:|||.::  .|||.|.:...|..|.:..||:|:|......:.|.||.:..|||
Zfish   303 VNGSGEHGFVVFTLGSMVS--QLPEAKAREFFEAFRQIPQRVLWRYTGPVPENAPKNVKLMKWLP 365

  Fly   347 QDDILAHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTAS 411
            |:|:|.|.||.||:||||.....|.|.:|.|:|.:|.||||..|..|....|...::....:|:.
Zfish   366 QNDLLGHPKVRAFVTHGGSHGIYEGICNGVPMVMLPLFGDQGDNAQRLVSRGVAESLTIYDVTSE 430

  Fly   412 LFRSAIERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQY 476
            ....|::::.:|.|:.|::..:|:.:||:...||:.||:|.|.|.|||||::||.|..|||:|||
Zfish   431 KLLVALKKVINDKSYKEKMMKLSAIHRDRPIEPLDLAVFWTEFVMRHKGAEHLRPAAHDLNWIQY 495

  Fly   477 HNLDVLATFFSVIGLTVIFV 496
            |:|||:. |..:|.||||||
Zfish   496 HSLDVIG-FLLLILLTVIFV 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	114/375 (30%)
ugt1ab	NP_998587.2	UDPGT	37..524	CDD:278624	153/525 (29%)
ugt1ab	NP_998587.2	egt	<279..513	CDD:223071	95/238 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.760