DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302E1 and Ugt316A1

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001287111.1	Gene:	Ugt316A1 / 40079	FlyBaseID:	FBgn0036842	Length:	636	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	157/515 - (30%)
Similarity:	262/515 - (50%)	Gaps:	43/515 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILALFGQSWGYSYLMISHTASKSHYAVCFALAKGL--AAAGHEVTLVSPFPQRKPIKNIIDVETP 74
            :|.:|...|            ||||.....|.:.|  ::..|.|||:||...::.    :|.|.|
  Fly    21 VLTVFPSVW------------KSHYLFGRRLLQELVESSGNHSVTLISPHAAQEG----VDAEIP 69

  Fly    75 NIITV-----------MGV-YKARILENAKKPVLLRYPRISLMGLDITESLLKEPKVQELLKQNR 127
            .|..:           ||: ::|.  |...:.|:.|:.|:...|....:.||.:|:|::||....
  Fly    70 KIRELRIEGLRENWLDMGMSFEAE--EMRAQSVMERFTRLIYAGTTNVDILLSDPQVRKLLTSGE 132

  Fly   128 TFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLVGTPSPPSYVPHSLLRFGDRMNFW 192
            .||.:|.:.|::||..|.|.::|.|.:.:|..||..|.:::.|.|...|..|.:.|.|.:|||..
  Fly   133 KFDLLIVDLFLSDALLGLAFYYGIPTVAVSPTGANSWLNNMFGNPQSSSLDPSNFLPFTERMNTR 197

  Fly   193 ERAQNLGFQIYEFAYENLINLPRHEALYRKYFP--NNKQDFYR-MRKDTSLVLLNNHVSISNPRP 254
            :|..|.....:|....|..:|...:::|..:|.  ..:...|| :.|:.||.|:|:|..:..||.
  Fly   198 QRILNSLMSTFERLTYNFFHLISQQSVYTNHFELLVKELPLYRDLTKNLSLALINSHPGLHYPRA 262

  Fly   255 YSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEAEHGVIYFSLGSNLNSKDLPENKRKAIVETLRGL 319
            |.|||:||||:|::......||:::..|:|.|..||||||||:::.:..||:.|...|::....|
  Fly   263 YLPNMVEVGGLHLSHLNDDNLPKHLLSFMESAPSGVIYFSLGADVETAQLPQEKLAIILDVFGHL 327

  Fly   320 K-YRVIWKYEEETFVDK---PDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMESIYHGKPVVG 380
            | :..:.|:|:|.|..:   |:||:|::|.||..||.|.:|..||:..|.||..|||...|||:.
  Fly   328 KEFHFLLKWEKEEFTAEQVLPENVMIADWWPQQAILHHPQVKMFISSCGQLSVWESISGQKPVLA 392

  Fly   381 IPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTERVKVISSQYRDQKETPL 445
            ||...:|.:...|.::.|..:||.|..|........|.::|.:.|:.|::..:..:...:..||:
  Fly   393 IPILAEQEVMAKRLQRHGVSVTVGYDSLAYDSLLHGIRQLTLNTSYVEKLGQLKERLISRDSTPV 457

  Fly   446 ERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVL----ATFFSVIGLTVIFVFLLVR 501
            .:||..::.:....||.:|:|....|||.:...:|||    ..||.::.:..:.:..::|
  Fly   458 GKAVRKIQLILESGGADFLKSHANTLNFWRAEGVDVLLIIAVGFFGILTIPFLAICFILR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	118/356 (33%)
Ugt316A1	NP_001287111.1	egt	1..480	CDD:223071	148/476 (31%)
Ugt316A1	NP_001287111.1	MGT	39..448	CDD:273616	133/414 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445641
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.850