DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and Ugt1a3

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_958827.1	Gene:	Ugt1a3 / 396551	RGDID:	1549728	Length:	531	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	154/532 - (28%)
Similarity:	255/532 - (47%)	Gaps:	78/532 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LNSWLLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPIKNII 69
            |:..|||:.||   .|.....::......||:.....:.:.|.|.||:..:::|       :..:
  Rat    10 LSGLLLLLCAL---PWAEGGKVLVFPMEGSHWLSMRDVVRELHARGHQAVVLAP-------EVTV 64

  Fly    70 DVETPNIITVMGV--------YKARIL---------ENAKKPVLLRYPRISLMGLDITES----L 113
            .::..:..|:...        |:..:|         |.:.|.||.|...::.:......|    |
  Rat    65 HIKEEDFFTLQTYPVPYTKEEYRHHLLGHLQNFFETEFSLKLVLQRMAAVNNVSTFYVRSCRGLL 129

  Fly   114 LKEPKVQELLKQNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLV--------G 170
            .....:|.|  .:.:||.|:.:.|.         ..||.|.....:.|..:...::        .
  Rat   130 HNTALIQSL--NSSSFDVVLTDPFF---------PCGAVLAMYLRVPAVFFLQSMLCELEFEATN 183

  Fly   171 TPSPPSYVPHSLLRFGDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKYFPNNKQDFYRMR 235
            :|:|.||:|..|....|.|:|.:|.:|:   :|...:..|.:: .:.:|.|.     ..|.  ::
  Rat   184 SPNPSSYIPRLLTLNSDHMSFLDRVKNM---LYPVPWMYLCHV-NYGSLARL-----ASDL--LQ 237

  Fly   236 KDTSLVLLNNHVSI---------SNPRPYSPNMIEVGGMH-VNRKAPKPLPQNIRKFIE-EAEHG 289
            ::.|:|.:..|.|:         ..|||:.|||:.:||:: .||   |||.|....::. ..|||
  Rat   238 REVSVVEILRHASVWLLRKDFVFYYPRPFMPNMVFIGGINCANR---KPLSQEFEAYVNASGEHG 299

  Fly   290 VIYFSLGSNLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKPDNVLISNWLPQDDILAHE 354
            ::.|||||.::  ::||.|...|.|.|..:...|:|:|......:...|.::..||||:|:|.|.
  Rat   300 IVVFSLGSMVS--EIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHP 362

  Fly   355 KVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIER 419
            |..|||||.|.....|.|.:|.|:|.:|.||||..|..|.|..|.|:|:...::||....:|::.
  Rat   363 KARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKT 427

  Fly   420 ITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLAT 484
            :.::.|:.|.:..:||.::|:...||:.||:|||:|.|||||.:||.|..||.:.|||:|||:.
  Rat   428 VINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIG- 491

  Fly   485 FFSVIGLTVIFV 496
            |...|.|||:|:
  Rat   492 FLLAIVLTVVFI 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	113/368 (31%)
Ugt1a3	NP_958827.1	UDPGT	26..522	CDD:278624	147/513 (29%)
Ugt1a3	NP_958827.1	egt	<228..505	CDD:223071	107/289 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860