DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302E1 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_958826.1	Gene:	Ugt1a2 / 396527	RGDID:	1549741	Length:	533	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	156/551 - (28%)
Similarity:	247/551 - (44%)	Gaps:	116/551 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LNSWLLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSP----------- 58
            |:..|||:.||   .|.....::......||:.....:.:.|.|.||:..:::|
  Rat    12 LSGLLLLLCAL---PWAEGGKVLVFPMEGSHWLSMRDVVRELHARGHQAVVLAPEVTVHMKGEDF 73

  Fly    59 -------FPQRKPIKNIIDVETPNIITVMGVYKARILENAKKPVLLRYPRISLMGLD-------I 109
                   ||..|.                 .|:..||.||||            |.:       .
  Rat    74 FTLQTYAFPYTKE-----------------EYQREILGNAKK------------GFEPQHFVKTF 109

  Fly   110 TESLLKEPKVQEL-------LKQNRT---------FDGVI------CETFMNDAHYGFAEHFGAP 152
            .|::....|..:|       |..|:|         ||.|:      |...:       |::...|
  Rat   110 FETMASIKKFFDLYANSCAALLHNKTLIQQLNSSSFDVVLTDPVFPCGALL-------AKYLQIP 167

  Fly   153 LITLSSLGATGWTSDLVGTPSPPSYVPHSLLRFGDRMNFWERAQNLGFQIYEFAYENL--INLPR 215
            .:........|...:....|.|.||:|:.|....|.|.|.:|.:|:   :|....:.:  :::..
  Rat   168 AVFFLRSVPCGIDYEATQCPKPSSYIPNLLTMLSDHMTFLQRVKNM---LYPLTLKYICHLSITP 229

  Fly   216 HEALYRKYFPNNKQDFYRMRKDTSLVLLNNHVSI---------SNPRPYSPNMIEVGGMHVNRKA 271
            :|:|..:.          ::::.|||.:.:|.|:         ..|||..|||:.:||  :|...
  Rat   230 YESLASEL----------LQREMSLVEVLSHASVWLFRGDFVFDYPRPIMPNMVFIGG--INCVI 282

  Fly   272 PKPLPQNIRKFIE-EAEHGVIYFSLGSNLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDK 335
            .|||.|....::. ..|||::.|||||.::  ::||.|...|.|.|..:...|:|:|......:.
  Rat   283 KKPLSQEFEAYVNASGEHGIVVFSLGSMVS--EIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNL 345

  Fly   336 PDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYG 400
            ..|.::..||||:|:|.|.|..|||||.|.....|.|.:|.|:|.:|.||||..|..|.|..|.|
  Rat   346 AKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAG 410

  Fly   401 ITVKYAQLTASLFRSAIERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLR 465
            :|:...::||....:|::.:.::.|:.|.:..:||.::|:...||:.||:|||:|.|||||.:||
  Rat   411 VTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR 475

  Fly   466 SACQDLNFIQYHNLDVLATFFSVIGLTVIFV 496
            .|..||.:.|||:|||:. |...|.|||:|:
  Rat   476 PAAHDLTWYQYHSLDVIG-FLLAIVLTVVFI 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	113/383 (30%)
Ugt1a2	NP_958826.1	UDPGT	28..524	CDD:278624	149/532 (28%)
Ugt1a2	NP_958826.1	egt	<261..507	CDD:223071	99/250 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860