DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and ugt-35

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001023694.1	Gene:	ugt-35 / 3565443	WormBaseID:	WBGene00044286	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	529	Identity:	134/529 - (25%)
Similarity:	228/529 - (43%)	Gaps:	51/529 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSP--------FPQRKPIKN 67
            ||..||..|...::|:.....:.||:.....:|..|:..||.||.::|        |...|...:
Worm    11 LISILFQNSKSVNFLVYCPLFAHSHHTFLAKIADTLSEEGHNVTFLAPIIVQKYENFKYLKHTTD 75

  Fly    68 II----DVETPNIITVMGVYKARILENAKKPVLLRYPRISL---MGLDITESLLKEPKVQELLKQ 125
            ||    |.|...:..:||..........:..|....|.|.|   |...|.|:|..:..:.:.||
Worm    76 IIYIQPDEELKKLGEIMGSAGFSKYWTEEPSVFSMIPSIKLFQKMFHKIYENLRADLSILDSLK- 139

  Fly   126 NRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWT-SDLVGTPSPPSYVPHSLLRFGDRM 189
            :|.||.:|.|....:| ....::.|...:..:.....|.. |..:|.|:.|:.:..:|..:|::|
Worm   140 DRKFDAMIYEVLAFNA-IAIQQYLGIKTLYPTFSVTHGMVLSKSIGEPASPATLSSALSPYGEKM 203

  Fly   190 NFWERAQNLGFQIYEFAYENLINLPRHEALYRKYFPNNKQDFYRMRKDTSLVLLNNHVSISNPRP 254
            ||.||..|   .:..|.|:..:..|:..:....|:   :.|........|.|.||::..:..|||
Worm   204 NFQERLMN---TVCAFIYQVFMKPPKMISYSHPYY---EIDLKEAESKASFVFLNSNPYLDFPRP 262

  Fly   255 YSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEAEHGV-------IYFSLGSNLNSKDLPENKRKAI 312
            .....:.:||:.||..      |...:.:.:..|.:       :..|.||.:.|.|:|:..:..|
Worm   263 MLTKTVLIGGISVNTS------QIREERLSDEYHNILNIRVKTVLISFGSIMLSTDMPDRYKSII 321

  Fly   313 VETLRGL-KYRVIWKYE--EETFVDKPDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMESIYH 374
            |:.:... ....|||||  |..|.:...|:....|:||..:||..::.|||||.||.|..|..|.
Worm   322 VKVIEEFPNVTFIWKYESDELDFANNLKNLHFFKWIPQTALLADSRLSAFITHAGLGSINELSYM 386

  Fly   375 GKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQL-TASLFRSAIERITSDPSFTERVKVISSQYR 438
            |||.:.:|.|.||..|.....:....|:::...| .....|.::.:|..|.||.|..::::.|..
Worm   387 GKPAILVPIFADQLRNAKMLVRHNGSISLEKQDLGNFEKLRVSLAKILKDNSFQENAEILARQLN 451

  Fly   439 DQKETPLERAVYWVEHVTRHKGAKY-----LRSACQDLNFIQYHNLDVLATFFSVIGLTVIFVFL 498
            :|..:|.|   ..::|.|  .||::     |....:.::|...:.:|:.......:.:.|.|:|.
Worm   452 NQPISPRE---LLIKHAT--FGAEFGELPSLDPYSRQMSFFSLNMIDIFLFLGVFLAILVYFLFT 511

  Fly   499 LVRFLVTIV 507
            .:|.|:.::
Worm   512 FLRLLLNLL 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	95/366 (26%)
ugt-35	NP_001023694.1	Glycosyltransferase_GTB_type	2..464	CDD:299143	122/469 (26%)
ugt-35	NP_001023694.1	UDPGT	34..506	CDD:278624	123/490 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	193	1.000	Inparanoid score	I2536
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860