DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_787040.2	Gene:	Ugt1a8 / 301595	RGDID:	708474	Length:	530	Species:	Rattus norvegicus

Alignment Length:	502	Identity:	154/502 - (30%)
Similarity:	240/502 - (47%)	Gaps:	74/502 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SHYAVCFALAKGLAAAGHEVTLVSPFPQRKPIKNI-IDVETPNIITVM----------------- 80
            ||:.....:.:.|:..||||.:|.|.......|:: ..|:|.::...:
  Rat    36 SHWFTMQMIVEKLSHRGHEVVVVIPEVSWHMGKSLNFTVKTYSVSYTLEDLNYHFKFFAHNQWKT 100

  Fly    81 ---GVYKARILENAKK---PVLLRYPRISLMGLDITESLLKEPKVQELLKQNRTFDGVICETFMN 139
               |::.  :|:::.|   .:|..:.|          ||.|:.|:.|.|||: :||.|..:.| :
  Rat   101 QEVGMFS--LLKHSGKGFFELLFSHCR----------SLFKDKKLVEYLKQS-SFDAVFLDPF-D 151

  Fly   140 DAHYGFAEHFGAPLITLSSLGATGWTSDLVGTPSPPSYVPHSLLRFGDRMNFWERAQNLGFQIYE 204
            ......|::|..|.:..|......:..:....||||||||..|.:|.|.|.|.||..|      .
  Rat   152 VCGLILAKYFSLPSVVFSGGIFCHYLDEGAQCPSPPSYVPRILSKFTDTMTFKERVWN------H 210

  Fly   205 FAYENLINLPRHEALYRKYF--------------PNNKQDFYRMRKDTSLVLLNNHVSISNPRPY 255
            .:|       ..|..:..||              |...:|.:   ...|:.:......:..|||.
  Rat   211 LSY-------MKERAFCPYFFKTAVEIASEVLQTPVTMRDLF---SPVSIWMFRTDFVLEFPRPV 265

  Fly   256 SPNMIEVGGMHVNRKAPKPLPQNIRKFIE-EAEHGVIYFSLGSNLNSKDLPENKRKAIVETLRGL 319
            .|||:.:||  :|....|||.:....::. ..|||::.|||||.::  ::||.|...|.|.|..:
  Rat   266 MPNMVYIGG--INCHQGKPLSKEFEAYVNASGEHGIVVFSLGSMVS--EIPEKKAMEIAEALGRI 326

  Fly   320 KYRVIWKYEEETFVDKPDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMESIYHGKPVVGIPFF 384
            ...|:|:|......:...|.::..||||:|:|.|.|..|||||.|.....|.|.:|.|:|.:|.|
  Rat   327 PQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLF 391

  Fly   385 GDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTERVKVISSQYRDQKETPLERAV 449
            |||..|..|.|..|.|:|:...::||....:|::.:.::.|:.|.:..:||.::|:...||:.||
  Rat   392 GDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAV 456

  Fly   450 YWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGLTVIFV 496
            :|||:|.|||||.:||.|..||.:.|||:|||:. |...|.|||:|:
  Rat   457 FWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIG-FLLAIVLTVVFI 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	118/364 (32%)
Ugt1a8	NP_787040.2	UDPGT	26..521	CDD:278624	154/502 (31%)
Ugt1a8	NP_787040.2	egt	<263..504	CDD:223071	97/245 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860