DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_766469.1	Gene:	Ugt2b35 / 243085	MGIID:	3576100	Length:	529	Species:	Mus musculus

Alignment Length:	567	Identity:	156/567 - (27%)
Similarity:	254/567 - (44%)	Gaps:	90/567 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRWLLNSWLLLILALFGQS-------WGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSP 58
            ::|:....||.:...|..:       |...:         ||:.....:...|...|||||::.|
Mouse     3 VKWISALLLLQMSCCFRSTSCGKVLVWPLEF---------SHWMNLKIILDELVQRGHEVTVLRP 58

  Fly    59 F------PQRKPIKNIIDVETPNIITVMGVYKARILE----NAKKPVLLRYPRI-SLMG--LDIT 110
            .      |:..|........|......:..:..::::    ...:...|.|..: :|.|  .|.:
Mouse    59 SASIFVDPKYSPGLKFETFPTAFSKDYLETFLTKLVDEWTFEVPRDTCLSYSLLQTLFGKLSDYS 123

  Fly   111 ESLLKEPKVQELLK---QNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGW--TSDLVG 170
            .||.||....:.|.   |...||.:|.:...:.... .|:....|.: .|...:.|:  ..:..|
Mouse   124 LSLCKEAVSNKQLMTKFQESKFDVLILDAMASCGEL-IAQLLQIPFL-YSLRFSPGYQVEKNSGG 186

  Fly   171 TPSPPSYVPHSLLRFGDRMNFWERAQNLGFQIY-EFAYENLINLPRHEALYRKYFPNNKQD-FY- 232
            ...||||||..|...|.:|.|.||.:|:...:| :|.::.              |...:.| ||
Mouse   187 FVLPPSYVPVILSGLGGQMTFTERVKNMICMLYFDFWFQT--------------FTEKEWDQFYS 237

  Fly   233 -RMRKDTSLV---------LLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEA- 286
             .:.:.|:|:         .:.::..:..|.|..||:..|||:|.  |..||||:.:..|::.:
Mouse   238 ETLGRPTTLIETMGKAEMWFIRSYWDLEFPHPTLPNVEYVGGLHC--KPAKPLPKEMEDFVQSSG 300

  Fly   287 EHGVIYFSLGSNLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKPDNVLISNWLPQDDIL 351
            .|||:.|||||.::  ::.|.:..||...|..:..:|:|:::.:|......|..|..||||:|:|
Mouse   301 VHGVVVFSLGSMVS--NMTEERANAISWALAQIPQKVLWRFDGKTPASLGPNTRIYKWLPQNDLL 363

  Fly   352 AHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSA 416
            .|.|..||:||||.....|:|:||.|::|||.|.:|..|:|.....|..:.:....::.|...:|
Mouse   364 GHPKTKAFVTHGGANGLYEAIHHGIPMIGIPLFSEQHDNIAHMVAKGTAVALNIRTMSRSDLLNA 428

  Fly   417 IERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDV 481
            :|.:.::||:.|.|..:|:.:.||...||.|.::|:|.|.||||||:||....:|.:.|||:|||
Mouse   429 LEEVINNPSYKENVMWLSTIHHDQPMKPLNRTIFWIEFVMRHKGAKHLRPLAHNLTWYQYHSLDV 493

  Fly   482 LATFFSVIGLTVIFVFLLVRFLVT---------IVNGFLYKPSSKLK 519
            :.             ||||..:.|         .|..|..|.:.|.|
Mouse   494 IG-------------FLLVCVVATAVLPVKCCLFVYQFFVKKAKKRK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	113/368 (31%)
Ugt2b35	NP_766469.1	egt	8..506	CDD:223071	150/539 (28%)
Ugt2b35	NP_766469.1	UDPGT	24..525	CDD:278624	150/542 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840479
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690