DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_038729.1	Gene:	Ugt1a2 / 22236	MGIID:	3576049	Length:	533	Species:	Mus musculus

Alignment Length:	517	Identity:	143/517 - (27%)
Similarity:	243/517 - (47%)	Gaps:	71/517 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEV----TLVSPFPQRKPIKNII- 69
            :|:|.:.|..|.....::....::.|..|..|....:...|.:.    |...|:.:.:..:.|:
Mouse    30 VLVLPMEGSQWLSMRDVVRELHARGHQTVVLASEVTVHIKGEDFFTLKTYAFPYTKEEYQQEILS 94

  Fly    70 DVE---------------TPNIITVMGVYKARILENAKKPVLLRYPRISLMGLDITESLLKEPKV 119
            |:|               |.:|.....:|....:......:|::....|...:.:|:.:..
Mouse    95 DIEKTFKTQHFVKAFFETTASIRNFFDLYSNSCIALLHNKMLIQQLNSSFFDVILTDPIFP---- 155

  Fly   120 QELLKQNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLVGTPSPPSYVPHSLLR 184
                          |...:       |::...|.:.:....:.|...:....|:|.||:|:.|.|
Mouse   156 --------------CGAVL-------AKYLQIPAVFILRSLSCGIEYEATQCPNPSSYIPNLLTR 199

  Fly   185 FGDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKYFPNNKQDFYRMRKDTSLVLLNNHVSI 249
            ..|.|:|.:|.||:.:.:. ..|...:::..:|:|..:.          ::::.|||.:.:|.|:
Mouse   200 LSDHMDFLQRVQNMLYYLV-LKYICRLSITPYESLASEL----------LQREVSLVEVLSHASV 253

  Fly   250 ---------SNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIE-EAEHGVIYFSLGSNLNSKDL 304
                     ..|||..|||:.:||  :|....|||.|....::. ..|||::.|||||.::  ::
Mouse   254 WLFRGDFVLDYPRPIMPNMVFIGG--INCVTKKPLSQEFEAYVNASGEHGIVVFSLGSMVS--EI 314

  Fly   305 PENKRKAIVETLRGLKYRVIWKYEEETFVDKPDNVLISNWLPQDDILAHEKVIAFITHGGLLSTM 369
            ||.|...|.|.|..:...|:|:|......:...|.::..||||:|:|.|.|..|||||.|.....
Mouse   315 PEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIY 379

  Fly   370 ESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTERVKVIS 434
            |.|.:|.|:|.:|.||||..|..|.|..|.|:|:...::||....:|::.:.::.|:.|.:..:|
Mouse   380 EGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLS 444

  Fly   435 SQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGLTVIFV 496
            |.::|:...||:.||:|||:|.|||||.:||.|..||.:.|||:|||:. |...|.|||:|:
Mouse   445 SLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIG-FLLAIVLTVVFI 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	107/359 (30%)
Ugt1a2	NP_038729.1	UDPGT	28..524	CDD:278624	143/517 (28%)
		Glycosyltransferase_GTB_type	43..>175	CDD:299143	18/156 (12%)
		egt	<261..505	CDD:223071	98/248 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840638
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690