DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and ugt-56

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_506074.2	Gene:	ugt-56 / 188073	WormBaseID:	WBGene00011453	Length:	524	Species:	Caenorhabditis elegans

Alignment Length:	577	Identity:	143/577 - (24%)
Similarity:	228/577 - (39%)	Gaps:	111/577 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRWLLNSWLLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPF------ 59
            |.|....| |..|.::|.:  :..|:.:....:||......:|..|||.||:||::...
Worm     1 MLWAFIVW-LGALCIYGSA--FDILIYAPRMMQSHVYFTARIANVLAARGHKVTVIDNVFRYDVD 62

  Fly    60 -PQRKPIKNIIDVETPNIITVMGVYKARILENAKKPVLL-------RYPRISLMGL--------- 107
             .....|..||.||....:|       ::|.....|.:|       ...|..:.||
Worm    63 NELSSDIHEIISVEPSPEVT-------KLLNTGSLPTILWNSKASPEEQRTIMEGLGHVHRLQCT 120

  Fly   108 DITESLLKEPKVQELLKQNRTFDGVICETFMNDAHYGFAEHFGA-PLITLSSLG------ATGWT 165
            .:.|:....||:||:     .||..|.|.| :....|..|..|. ..:.:||.|      .|...
Worm   121 HLIENSTLIPKLQEI-----KFDFAIHEVF-DSCGVGILEVIGVQKTVIVSSTGPMDVVPITLGI 179

  Fly   166 SDLVGTPSPPSYVPHSLLRFGDRMNFWERAQNLGFQIYEFAYENLINLPRHE-------ALYRKY 223
            ||.:.|||       .|..:|..::|:|:.:||.|      ...::|.  ||       .|::||
Worm   180 SDTLNTPS-------LLSDYGSYLSFFEKRRNLKF------LSGMLNF--HEMQDSMISPLFKKY 229

  Fly   224 FPNNKQDFYRMRKDTSLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEAEH 288
            :...|.....||: .:|:..|.|......|.......::||  :..|..|.|....:..:.:...
Worm   230 YGLKKPTGEIMRQ-ANLLFYNIHEGSDGMRMRGRRSFDIGG--IAFKDQKNLTMEYQTLLSDPRP 291

  Fly   289 GVIYFSLGSNLNSKDLPENKRKAIVETLRGL-KYRVIWKYE-EETFVDKPD---NVLISNWLPQD 348
            .|: .|.|:...|..:|:|.:.:::..::.: ....||||| |:.|..:.:   |::...:|||.
Worm   292 KVL-VSFGTAATSSHMPQNLKNSLMTAMKQMNNVLFIWKYEMEDNFTKQEELTTNIIFKKFLPQT 355

  Fly   349 DILAHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLF 413
            |:||..|:..|:||.|..|.:|:...|..|:.:|.||||..|...|.:.|         |...|.
Worm   356 DLLASSKIDLFVTHCGQNSLLEAFNSGVRVLAVPLFGDQHRNAKLAFENG---------LIEILP 411

  Fly   414 RSAIER-----------ITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSA 467
            :|.||.           :..:....:.:.:|||..|:.||......:..:|       |.|  |.
Worm   412 KSDIETPAKIVKAVKTGLEPNAKLDQNIVLISSLLRNSKENAENLLISTIE-------ATY--ST 467

  Fly   468 CQDLNFIQ----YHNLDVLATFFSVIGLT-VIFVFLLVRFLVTIVNGFLYKPSSKLK 519
            ....||.:    ||...::....|.|.|. ::|:|:.|........||.|..|...|
Worm   468 EFPPNFSKFPKNYHPNTLVRLIDSSIALVFMLFIFVFVNHFRKNYVGFKYPLSFSTK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	96/379 (25%)
ugt-56	NP_506074.2	Glycosyltransferase_GTB_type	<216..>399	CDD:299143	51/186 (27%)
ugt-56	NP_506074.2	Glycosyltransferase_GTB_type	<353..453	CDD:299143	33/108 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810