DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and ugt-8

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_504315.1	Gene:	ugt-8 / 186768	WormBaseID:	WBGene00019234	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	551	Identity:	144/551 - (26%)
Similarity:	223/551 - (40%)	Gaps:	91/551 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPIKNIIDVET 73
            ||.||.:.|.....:.|:.:.....||......:|..:|..||.|||..||  ...:||...:..
Worm     6 LLSILLVLGSVSCKNILIFNPIFGLSHVKFISKMANIIADHGHNVTLFQPF--HIALKNTEGLIK 68

  Fly    74 PNIITVMGVYKARILENAK----------------KPVLLRY--PRISLMGLDITES-LLKEPKV 119
            ...|.::..|.....|..|                .|||..:  |:......:.|.: |||:...
Worm    69 NKYIEIINYYPDHYDELLKTETATFPAFWDSHLMNNPVLSAFMIPKAIAGEFERTATQLLKDKVA 133

  Fly   120 QELLKQNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWT--SDLVGTPSPPSYVPHSL 182
            .:.|| :|.||.:|.|||.....| .|.....|.|.:.|  |..:|  :::.|.||...|
Worm   134 LDDLK-SRNFDVIISETFELTGMY-IAHMLNVPCIPVWS--AVRFTIFNNIFGQPSSLGY----- 189

  Fly   183 LRFGDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKYF--------PNNKQDFYR------ 233
                .:..|.:.|...||            :.|...:||.:|        ...:.||..
Worm   190 ----SQQPFSKLAPEAGF------------IDRLNDVYRNFFFTITMDGMGQYQNDFIEKAVGRP 238

  Fly   234 ------MRKDTSLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPK---PLPQNIRKFIEEAEHG 289
                  :.|:..:...|::..:....|.:..::.:||..::.:..|   |||....|.:||.|..
Worm   239 LPYWKDLIKEAPVYFTNSNEYLDFAVPTTATIVHIGGFTMDLEKMKHVDPLPDKYAKILEEREST 303

  Fly   290 VIYFSLGSNLNSKDLPENKRKAIVETLRGL-KYRVIWKYEEE--TFVDK-PDNVLISNWLPQDDI 350
            |: .|.||.:.|..:|:|.:..|::....| ....|||||.:  .|..| |.||.:..|:||..:
Worm   304 VL-ISFGSVIRSYQMPDNFKAGIIKMFESLPDVTFIWKYERDDVEFQKKLPKNVHLKKWVPQHSL 367

  Fly   351 LAHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITV-KYAQLTASLFR 414
            ||..:|..|:|||||.||||..|.|||.:.:|.||||..|.....:.|..|:. |:.........
Worm   368 LADNRVKLFVTHGGLGSTMEVAYTGKPALMVPIFGDQPENANMLARHGGAISYDKFELADGEKLA 432

  Fly   415 SAIERITSDPSFT----ERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRS---ACQDLN 472
            ..|..:..:|.:.    |.:||:|.|       |::..:..::|:........|||   |...:.
Worm   433 ITIRDMVRNPKYNKNAQELLKVLSHQ-------PIDPKLNLMKHLEFAMEFPNLRSQVPAINQMG 490

  Fly   473 FIQYHNLDVLATFFSVIGLTVIFVFLLVRFL 503
            .|.::.|||:.....:..|||...|.::..|
Worm   491 LIAHYYLDVIFFLSLIFILTVYLTFKIISLL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	102/383 (27%)
ugt-8	NP_504315.1	UDPGT	30..516	CDD:278624	136/520 (26%)
ugt-8	NP_504315.1	egt	<284..462	CDD:223071	64/185 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810