DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302E1 and ugt-37

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_504811.2	Gene:	ugt-37 / 184293	WormBaseID:	WBGene00017332	Length:	528	Species:	Caenorhabditis elegans

Alignment Length:	564	Identity:	149/564 - (26%)
Similarity:	234/564 - (41%)	Gaps:	90/564 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPIKNIIDVET 73
            |:|:.|.|..::.|::|:.|.....||......:|..|:.|||.||..:|...||..|......|
Worm     4 LILLFACFNVNFSYNFLIFSPLFGHSHTTFFAKIADTLSEAGHNVTFFTPTIIRKFSKINYVKHT 68

  Fly    74 PNIITVMGVYKARILENAKKPVLL------------RYPRISL-------------MGLDITESL 113
            .::|.:....|.....|..:.|.:            .:|.|.|             ..||:.:.
Worm    69 KHVIHLEPSEKLERYGNQMEDVDISRFWTDDSSMAEMFPMIKLFNEMFAEQAFVLGQNLDVLDE- 132

  Fly   114 LKEPKVQELLKQNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDL---------V 169
            |||.|          ||.:|.|.|...|:         ||:....:.....:|.|         :
Worm   133 LKEMK----------FDVMIFERFAECAY---------PLLEYLEIETFIPSSSLLFDPNLLISI 178

  Fly   170 GTPSPPSYVPHSLLRFGDRMNFWERAQN-LGFQIYEFAYENLINLPRHEALYRKYFPNNKQ-DFY 232
            |.|..||.||..:.:|.|:|...||..| :...|:...      ||.||  ::.:.|..:. |..
Worm   179 GEPRIPSTVPLPMSKFTDKMTMTERLLNAIAVPIFHSL------LPTHE--FKSFRPPYQAIDIQ 235

  Fly   233 RMRKDTSLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEE------AEHGVI 291
            :|...:|.:|.|::..|..|||.....:::||:.|:.:..|     |.|..||      .....|
Worm   236 KMEHLSSFILSNSNPYIDYPRPTLEKNVQIGGISVDVENLK-----IHKVNEEWDRILDMRQKTI 295

  Fly   292 YFSLGSNLNSKDLPENKRKAIVETLRGL-KYRVIWKYE---EETFVDKPDNVLISNWLPQDDILA 352
            ..|.||.:.|||:|...:|.:.:|::.. :...|||||   .:.|..:.:|:..|:|:||..:||
Worm   296 LVSFGSVMLSKDMPVENKKILAKTMKQFPEVTFIWKYEFNDTDLFASETENIHFSSWVPQTALLA 360

  Fly   353 HEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITV-KYAQLTASLFRSA 416
            ..::.||.||.||.|..|..|.|||.:..|.|.||..|.....:....|.: ||...........
Worm   361 DRRLTAFFTHAGLGSVNEVSYLGKPSIMCPIFADQMRNAKMLARHNGSIEISKYDLGNGEKIEKT 425

  Fly   417 IERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDV 481
            :..|..|.|:....:.::.|..:|...|.|..:...|...:......|....:.|:|::|..:||
Worm   426 LRTILFDDSYRLSAEKLAHQLANQPVKPKELLLRHAEFAAQFGRLPSLDPYSRQLSFVEYFLIDV 490

  Fly   482 LA--TFFSVIGLTVIFVFL--LVRFLVTIVNGFLYKPSSKLKIN 521
            .|  .|.|::.:.|:|..:  |:.||...|:      |.|:|.|
Worm   491 AAILIFSSLLIVVVLFQIIKRLINFLPVTVD------SRKVKTN 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	100/371 (27%)
ugt-37	NP_504811.2	Glycosyltransferase_GTB_type	1..504	CDD:299143	139/532 (26%)
ugt-37	NP_504811.2	UDPGT	37..510	CDD:278624	132/505 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	193	1.000	Inparanoid score	I2536
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860