DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302E1 and ugt-40

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_504810.2	Gene:	ugt-40 / 184292	WormBaseID:	WBGene00017331	Length:	526	Species:	Caenorhabditis elegans

Alignment Length:	539	Identity:	134/539 - (24%)
Similarity:	226/539 - (41%)	Gaps:	66/539 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SWLLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSP--------FPQRK 63
            |..|..|.|...:..|:.|:.......||......||..|..|||.|||.||        :...|
Worm     5 SLYLYYLLLISSTTSYNILVFCPLFGHSHSTFFGRLADILTEAGHNVTLFSPTIIDEFRNYSYTK 69

  Fly    64 PIKNIIDVETPNIITVMGVYKARILENAK----KPVLLRYPRISLMGLDITES----LLKEPKVQ 120
            ..|::..::....:..:|   ..|..|.:    :..:...|:.:.....||..    |.....:.
Worm    70 LTKDVAYLDPSPELKAIG---DLIAGNKRWWNQEFSVFEIPQTTRFFKSITREQNNVLANNLALL 131

  Fly   121 ELLKQNRTFDGVICET----------FMNDAHYGFAEHFGAPLITLSSLGATGWTSDLVGTPSPP 175
            :.|||.: ||.::.|:          ::....:..|:......|||.:||.|..|
Worm   132 DGLKQKK-FDLILFESVFTCALPLMEYLEIKSFAVAQSIAYEPITLGALGDTVMT---------- 185

  Fly   176 SYVPHSLLRFGDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKYFPNNKQDFYRMRK--DT 238
            |::|:.:.:..|:|:..||..|...|.       ::|:......|.:.:.|.::..|.:.|  :.
Worm   186 SHIPNLMAQSSDKMSLCERMLNTLIQA-------MLNVYGMTPEYYQSYTNPEKKIYTLEKLSEA 243

  Fly   239 SLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEE------AEHGVIYFSLGS 297
            |.:.:|::..:..||......|::||:.||....|    :..|..||      .....:..|.||
Worm   244 SFIFMNSNPFLDFPRATITKNIQIGGISVNLDTLK----SSGKLTEEWDQILNLREKTLLVSFGS 304

  Fly   298 NLNSKDLPENKRKAIVETLRGLK-YRVIWKYE---EETFVDKPDNVLISNWLPQDDILAHEKVIA 358
            .:.|:|:|...:..:...::.|. ...|||||   ::.|.:...|:..|.|:||.::||..::.|
Worm   305 VILSQDMPFAYKVGLTNAMKQLNDVTFIWKYEGDDKKEFANGIKNIHFSKWVPQRELLADPRLSA 369

  Fly   359 FITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITV-KYAQLTASLFRSAIERITS 422
            |:|||||.|..|..|.|||.:..|..|||..|....|:....|.. ||......:..:|..:|..
Worm   370 FMTHGGLGSVNEVSYFGKPTIMCPLSGDQMRNAKMLERHNGSIEFSKYDLHNEKVVANAFRKILY 434

  Fly   423 DPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFS 487
            |.|:|...|.:|...:.|...|.|..:..||...|......|....:.:.||||..:|:.....:
Worm   435 DESYTLSAKRLSEHLQFQPVKPKELFLKHVEFAARFGKLPSLDPYSRQMGFIQYFLIDIAFIVLT 499

  Fly   488 VIGLTVIFV-FLLVRFLVT 505
            |: ||::.| :.:::|:.:
Worm   500 VV-LTIVSVLYFVLKFVAS 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	95/372 (26%)
ugt-40	NP_504810.2	YjiC	22..447	CDD:224732	111/449 (25%)
ugt-40	NP_504810.2	Glycosyltransferase_GTB_type	<247..503	CDD:299143	74/260 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	193	1.000	Inparanoid score	I2536
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860