DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302E1 and ugt-7

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_504343.2	Gene:	ugt-7 / 182577	WormBaseID:	WBGene00015739	Length:	530	Species:	Caenorhabditis elegans

Alignment Length:	568	Identity:	148/568 - (26%)
Similarity:	242/568 - (42%)	Gaps:	98/568 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLILALFGQ-SWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVT-----LVSPFPQRKPIKNI 68
            |:.|..|.| |:.:.||:||...|.||......:|..||..||||.     :|.....:|.|||
Worm     3 LVFLTFFLQYSYAFKYLIISPIYSYSHVKFMSNIADTLADHGHEVVVFQQQIVEALRDKKVIKN- 66

  Fly    69 IDVETPNIITVMGVYKA-----RILENAKKPVLLRY--------PRIS-----LMGLDITESLLK 115
                 |:|..:.  |:|     ....|..|..:.:|        |..:     .|..|:....|:
Worm    67 -----PDIKIIN--YEANTAGKEFYRNRPKSSVTKYWTTNQAANPSAADQFAEAMSKDLEHMCLQ 124

  Fly   116 --EPKVQELLKQNRTFDGVICETFMNDAHYGFAEHFGAP--LITLSS--LGATGWTSDLVGTPSP 174
              |.|....:.::..||.::.|.|.....| ..::...|  ::.::|  :....|.   :|.||.
Worm   125 VFEDKSLHTMLKSEHFDVLLAEPFDPCGLY-LGDYLKIPSTIVAMASSRIDPVQWA---LGQPSG 185

  Fly   175 PSYVPHSLLRFGDRMNFWERAQNLGF-----QIYEFAYENLINLPRH--------------EALY 220
            .:::|....::|:....|:|..|:..     :::...|.||::..|.              |:.|
Worm   186 LNFIPGPDSKYGEESGVWDRINNVWMFFMRTRMFRAVYWNLLDKLRFKTGLEIRNIDEIVAESAY 250

  Fly   221 RKYFPNNKQDFYRMRKDTSLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKP--LPQNIRKFI 283
            ..|..|...||                    |.|.....:.:||..:|....|.  ||:|::..:
Worm   251 LFYNSNPYLDF--------------------PFPSLTKCVPIGGFSMNTTNWKSENLPENLKNIL 295

  Fly   284 EEAEHGVIYFSLGSNLNSKDLPENKRKAIVETLRGLK-YRVIWKYEEETFVDK----PDNVLISN 343
            ::..: .::.|.||.:.|.|:|:..:.||:|..:.:. ...|||||:|...:.    |:||.:..
Worm   296 QKRPN-TVFISFGSVIRSADMPQEYKNAIIEVTKLMSDVTFIWKYEDEKDEEMRGNIPENVHLMK 359

  Fly   344 WLPQDDILAHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMN--MARAEQMGYGITVKYA 406
            ||||..:||..:|..|||||||.|.||..|.|||.:.||.|.||.||  |.| ...|..:..|:.
Worm   360 WLPQPALLADSRVSLFITHGGLGSIMEVAYSGKPAIVIPLFFDQPMNGEMLR-RHGGAEVYSKFE 423

  Fly   407 QLTASLFRSAIERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDL 471
            ...|...:..|:.:..:|.:....|.:|:..:.|...|:||.|...|.....|....|....:.|
Worm   424 LSNAKKLKKVIQNMIQNPKYLANAKKLSNLLQKQPINPIERLVKHAEFAAEFKKLPELDPYSRHL 488

  Fly   472 NFIQYHNLDVLATFFSVIGLTVIFVFLLVRFLVTIVNGFLYKPSSKLK 519
            ||.|:..||::||...:..|:.:||:.:...:.::      :..||::
Worm   489 NFFQFFFLDIVATLLILFMLSALFVYWITYVICSV------RSKSKME 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	100/383 (26%)
ugt-7	NP_504343.2	egt	1..477	CDD:223071	133/507 (26%)
ugt-7	NP_504343.2	UDPGT	27..521	CDD:278624	136/527 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810