DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302E1 and ugt-50

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_741913.1	Gene:	ugt-50 / 181413	WormBaseID:	WBGene00011564	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	556	Identity:	139/556 - (25%)
Similarity:	251/556 - (45%)	Gaps:	78/556 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRWLLNSWLLLILALFGQSW---GYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSP---- 58
            |||:    ...:.||...|:   ....|:...:.||||..:|...|..|..|||:..|..|
Worm     6 MRWM----FFCLTALLHGSFIVNAAKILVYCPSISKSHVLLCSKYADLLHNAGHDTVLFIPSYSK 66

  Fly    59 ----FPQRKPIK-----NIIDVETPNIITVMGVYKARILENAKKPVLLRYPRISLMGLDITESLL 114
                :...|..|     |:.:.....:.|:     |.::||:....:.|....:...:|:...||
Worm    67 LLDNYDGAKHAKVWRLHNVTEAYDTKLGTL-----ANVMENSHIGFIDRLTFDADFWIDMCADLL 126

  Fly   115 -KEPKVQELLKQNRTFDGVICETFMNDAHYGFAEHFGAP-LITLSS---LGATGWTSDLVGTPSP 174
             |.|::|.::  :..||.||... ::.........|..| .:.|||   :....|.   :|.|:.
Worm   127 GKLPEMQHII--DYKFDLVIYNE-IDPCTPAIVRLFNIPKTVLLSSEAIMDKVAWN---LGLPTL 185

  Fly   175 PSYVP-------HSLLRFGDRMNFWERAQNLGFQIYEFAYENLINLPR--HEA-LYRKYFPNNKQ 229
            |||||       |      |||:|:||..|    :|:|....:::..:  |.. |:||...::..
Worm   186 PSYVPSVEENPNH------DRMSFFERMSN----VYKFFQSIVVHYLQDIHVLNLFRKEVSSDFP 240

  Fly   230 DFYRMRKDTSLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEAEHGVIYFS 294
            ....:.::.||||:|.......||.||...:.||.:...:.....||:....:.::.:.|.::.|
Worm   241 SIAEIIRNVSLVLVNTDEIFDLPRSYSSKFVYVGMLEAGKDENVTLPKKQDDYFKKGKSGSVFVS 305

  Fly   295 LGSNLNSKDLPENKRKAIVETLRGL-KYRVIWK--YEEET---FVDKPDNVLISNWLPQDDILAH 353
            .|:....:.|||..:.:|:..::.| .|..:.|  .::|:   |.....||.:.:|:||..:|.|
Worm   306 FGTVTPFRSLPERIQLSILNAIQKLPDYHFVVKTTADDESSAQFFSTVQNVDLVDWVPQKAVLRH 370

  Fly   354 EKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIE 418
            ..:..|::|||:.|.:|::|:|.|:|.:|.|.|||.|....|:.|.|..|....:....|..||.
Worm   371 ANLKLFVSHGGMNSVLETMYYGVPMVIMPVFTDQFRNGRNVERRGAGKMVLRETVVKETFFDAIH 435

  Fly   419 RITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLA 483
            .:..:.|::..||.||...:::..|..||...|::.|.:::.:::......:|:.|::::||
Worm   436 SVLEEKSYSSSVKRISHLMKNKPFTSEERVTKWIDFVLKYETSEHFDLESNNLSIIEHNHLD--- 497

  Fly   484 TFFSVIGLTVIFVFLLVRFLVTIVNGFLYKPSSKLK 519
                      :|.:|.:   ::::|..:|:...|.|
Worm   498 ----------LFFYLCI---ISLLNFVVYRKIFKRK 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	100/370 (27%)
ugt-50	NP_741913.1	egt	9..475	CDD:223071	126/490 (26%)
ugt-50	NP_741913.1	UDPGT	26..520	CDD:278624	132/530 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3869
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840