DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and ugt-33

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_505692.2	Gene:	ugt-33 / 179464	WormBaseID:	WBGene00007946	Length:	522	Species:	Caenorhabditis elegans

Alignment Length:	542	Identity:	157/542 - (28%)
Similarity:	253/542 - (46%)	Gaps:	50/542 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NSWLLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRK------- 63
            |:..|..|.|.|....::||:.....:.||:.....:|..|..|||.||.::|...||
Worm     3 NTLFLCTLFLVGFVQPFNYLVFCPLYAHSHHKFLAKIADTLTDAGHNVTFLAPIVLRKYENVKYL 67

  Fly    64 -PIKNIIDVETPNIITVMGV---YKARILENAKK----PVLLRYPRISLMGLDITESLLKEPKVQ 120
             ..|:|:.::....:..:|.   |.....|:|..    |.:..:.:   |.:.:.|.|.|:..|.
Worm    68 ESTKDIVYIQPSKELEALGFTSNYSKFWTEDATAIQFVPAVRTFVK---MFVQLYEDLKKDLSVL 129

  Fly   121 ELLKQNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWT--SDLVGTPSPPSYVPHSLL 183
            :.|| ||.||.::.| |:....:..||:.|...: |.||..|..|  |..:|.||.|:.:|..:.
Worm   130 DELK-NRNFDAIVFE-FLCPTAFPIAEYLGIKAL-LPSLSMTHHTQMSRWIGEPSSPTVLPSMIS 191

  Fly   184 RFGDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKYFPNNKQDFYRMRKDTSLVLLNNHVS 248
            .|||.||||||   ||..:.:..:...:::||..:...   |..|.|||.|......:.:|::..
Worm   192 SFGDDMNFWER---LGNTLGDVFFTLFVDMPRMTSFSD---PERKIDFYEMSVRAPFMFMNSNPY 250

  Fly   249 ISNPRPYSPNMIEVGGMHVN--RKAPKPLPQNIRKFIEEAEHGVIYFSLGSNLNSKDLPENKRKA 311
            :...||.....:.:||:.||  :...|.|.:...|.|.|.:..:: .|.||.:.|||:|:..:..
Worm   251 LDYARPILTKTVLIGGISVNVTQLKQKKLNEKYDKIISERQQNIL-ISFGSMIFSKDMPDVYKNT 314

  Fly   312 IVETLRGL-KYRVIWKYEEE--TFVDKPDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMESIY 373
            :|:.::.. ....||||||:  :|.....|:..|.|:||..:||..::.||:||.||.|..|..|
Worm   315 LVQVIKSFPNVTFIWKYEEDDVSFAKHLPNLHFSKWVPQTALLADSRLSAFVTHAGLGSVTELSY 379

  Fly   374 HGKPVVGIPFFGDQFMNMARAEQMGYGITV-KYAQLTASLFRSAIERITSDPSFTERVKVISSQY 437
            .|||.|.||.|.||..|.....:....||: ||...:....|.||..|.:|..:....:::|.|.
Worm   380 MGKPAVLIPLFADQLRNSKTLSRHNGSITLSKYDLSSFEKLRFAINTILNDERYKINAEILSQQL 444

  Fly   438 RDQKETPLERAVYWVEHVTRHKGAKY-----LRSACQDLNFIQYHNLDVLATFFSVIGLTVIFVF 497
            :||..:|....|...|.     ||||     |....:.::||.::.||::.....::..|.|.:.
Worm   445 QDQPVSPHALLVKHAEF-----GAKYGELPNLDPCSRQMSFISFYMLDIIVFVGFILITTTIGIV 504

  Fly   498 LLVRFLVTIVNGFLYKPSSKLK 519
            |.|::::.    |.:|...|::
Worm   505 LTVKWILK----FCFKQKQKIQ 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	116/362 (32%)
ugt-33	NP_505692.2	Glycosyltransferase_GTB_type	1..498	CDD:299143	150/512 (29%)
ugt-33	NP_505692.2	UDPGT	31..520	CDD:278624	149/510 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	193	1.000	Inparanoid score	I2536
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14625
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3869
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.890