DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302E1 and ugt-1

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_505671.1	Gene:	ugt-1 / 179449	WormBaseID:	WBGene00007072	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	571	Identity:	152/571 - (26%)
Similarity:	248/571 - (43%)	Gaps:	109/571 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSP-----FPQRKPIKN- 67
            |.|:|......:.:::|::|.....||......:|..||...|.||::..     |.:.:..||
Worm     4 LFLLLTSLTFCYSHNFLVVSPVFGYSHMKFMNKVADTLANGDHNVTILQTYNYEHFGKIRMAKNT 68

  Fly    68 ---IID--------VETPNIITVMG-VYKARILEN------AKKPVLLRYPRISLMGLDITESLL 114
               |:|        |...|..:... ::...|:.|      |...||  |..:..|    .|.:|
Worm    69 NVEILDYHLDESKAVSNENSASAFKYMWNTEIINNPITGAIATSTVL--YGEMKTM----CEKVL 127

  Fly   115 KEPKVQE-LLKQNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLVGTPSPPSYV 178
            .:.|:.: :|.:|  |||.|.|.|.....| ..:|....:|.:.|...:..:...:|.||..:::
Worm   128 LDKKLHKWILSKN--FDGFISEPFDFCGLY-LGDHLKLNIIPMHSSTKSLPSVYAIGEPSLLNFL 189

  Fly   179 PHSLLRFGDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKYFPNNKQDFYRMRKDTSLVLL 243
            |....:||.....::|   :|         ::|.||..|..:.|.|  .||  |:....    ||
Worm   190 PSMRTKFGTEQTVFDR---IG---------DIIALPCLELAFSKLF--EKQ--YKQASQ----LL 234

  Fly   244 NNHVS-------------------ISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEAEHG 289
            |..|.                   |:.|.|..|..:.:||..::.      |:|::  :||..:.
Worm   235 NGDVRHWKEILQTATFYFSNANDFIAFPTPSLPKHVHIGGFTIDP------PKNLK--LEEEYNK 291

  Fly   290 V-------IYFSLGSNLNSKDLPENKRKAIVETLRGL-KYRVIWKY--EEETFVDK-PDNVLISN 343
            :       :..|.|:.:.|.|:||:.:..|::....| ....||||  |::.|::: |:|.::..
Worm   292 ILSLRKSTVLISFGTVIQSADMPESFKDGIIKMFHLLPDTTFIWKYEVEDQQFIERLPNNAILKK 356

  Fly   344 WLPQDDILAHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITV--KYA 406
            |:||..:||..::..|:|||||.||:|..|.|||.:.||.||||.:|.....:.| |.||  ||.
Worm   357 WVPQPALLADPRLKLFVTHGGLGSTLEVAYSGKPALMIPVFGDQLLNAKMLSRHG-GATVFDKYD 420

  Fly   407 QLTASLFRSAIERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQD- 470
            ...|....|||:.|..:..|.::...|:...|:|   |::.....::||  ...||:.|....:
Worm   421 LEDAEKLTSAIKEIIGNEEFNKKSHHIADLLRNQ---PIDPKANLLKHV--EFSAKFGRVDALEP 480

  Fly   471 ----LNFIQYHNLDVLATFFSVIGLTVIFVFLLVRFLVTIVNGFLYKPSSK 517
                .||:||:.||..|..||::    |.:|.|...|...|...::|..||
Worm   481 YNVHYNFVQYYMLDAFAIIFSIL----IIIFYLAHLLFKFVYKHVFKTKSK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	106/382 (28%)
ugt-1	NP_505671.1	UDPGT	28..528	CDD:278624	147/547 (27%)
ugt-1	NP_505671.1	egt	<190..494	CDD:223071	94/337 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810