DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and ugt-22

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_502633.1	Gene:	ugt-22 / 178330	WormBaseID:	WBGene00007455	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	559	Identity:	137/559 - (24%)
Similarity:	240/559 - (42%)	Gaps:	75/559 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NSWLLLILALFGQSWG----YSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSP---FPQR- 62
            |::||.:|.|.|...|    |..||.::....||..:..|::..|..|||::|::.|   |.|.
Worm     4 NTFLLPLLLLLGSFVGLTEPYKILMYTNLFGHSHIKMLGAVSDTLTDAGHDLTVLMPVIDFKQEN 68

  Fly    63 ----KPIKNIIDVETPNIITVMGVYKARILENAKK------------PVLLRY--PRISLMGLDI 109
                |..||||.::....|       ::.:|..:|            |:.:.:  |.:|.:....
Worm    69 KTAMKSTKNIIKIQPGQDI-------SKTIETMEKFMTQLWTTDNSNPLFMVFHAPAMSAIFASQ 126

  Fly   110 TESLLKEPKVQELLKQNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLVGTPSP 174
            ...:|::.::.|.|:. ..||..|.|.|...|:..|........:.:.|.......|..:|.|..
Worm   127 CRKVLEDKELIERLRA-ENFDLAITEPFDTCAYALFEAIKIRAHVAVLSCSRLDHVSKAIGQPIA 190

  Fly   175 PSYVPHSLLRFGDRMNFWERAQN-LGFQIYEFAYENLINLPRHEALYRKYFPNNKQDF------- 231
            |||||.:....|:||..|:|..| |.|.:.:|.:..:                ..:||
Worm   191 PSYVPGTQSTHGERMTIWQRFMNILHFLMGDFLFSYI----------------GDEDFKVAKEII 239

  Fly   232 -----YRMRKDTSLVLLNNHVSISN-PRPYSPNMIEVGGMHV-NRKAPKPLPQNIRKFIEEAEHG 289
                 :|.....:..:..||:.:.: |.|....:|.:||:.| .:|....||:...|.:...:..
Worm   240 PGVRSWREVLPEASFIFTNHIPLMDFPAPTFDKIIPIGGISVKTQKKSLELPEKWNKILGLRKKN 304

  Fly   290 VIYFSLGSNLNSKDLPENKRKAIVETLRGL-KYRVIWKYEEE--TFVDKPDNVLISNWLPQDDIL 351
            :: .|.|||..|.|:||:.::.:::....: ....|||||.|  |..|..|||.:.:||||:::|
Worm   305 IL-VSFGSNARSADMPEHFKQNVLKVAESMPDVTFIWKYENEKDTLADHLDNVYLGDWLPQNELL 368

  Fly   352 AHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQL-TASLFRS 415
            ...::..|:|||||.|..|....|||.|.:|.|.||..|....::.|....:....| .|...|:
Worm   369 GDPRLSLFVTHGGLASVTELALMGKPAVMVPLFADQARNANMLKRHGGAAVLHKTDLGNAETIRN 433

  Fly   416 AIERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLD 480
            .|:::..:..:....:.::....:|...|.:..:..||...:......:....:..::|:|:.||
Worm   434 TIKKVLENEKYRVNAERLAEMLNNQPTNPKDTLIKHVEFAAKFGQLPSMDPYGRHQSYIEYYLLD 498

  Fly   481 VLATFFSVIGLTVIFVFLLVRFLVTIVNGFLYKPSSKLK 519
            :::....:|..|....|.|::....:..|     |.|:|
Worm   499 IISIALVLILTTSFISFQLIKCTFRMCCG-----SGKVK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	93/368 (25%)
ugt-22	NP_502633.1	UDPGT	36..530	CDD:278624	125/523 (24%)
ugt-22	NP_502633.1	egt	<256..515	CDD:223071	68/259 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.698165	Normalized mean entropy	S5056
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14115
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.760