DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and ugt-45

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_500410.2	Gene:	ugt-45 / 177139	WormBaseID:	WBGene00021372	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	524	Identity:	131/524 - (25%)
Similarity:	237/524 - (45%)	Gaps:	42/524 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVS----PFPQR-KPIKNI 68
            :.|:|.:...:..|..|:.......||......||..|..|||:||.:.    |.||. ..:..:
Worm     5 VFLLLFVLPAASCYKILVSVPKFGFSHMQTMGKLADILVEAGHDVTFLMPVDVPIPQNGTELAKV 69

  Fly    69 IDVETPNIIT-VMG-VYKARIL-------ENAKKPVLLRYPRISLMGLDITESLLKEPKVQELLK 124
            :.|.|.:.|. :|| ..|:..:       .|:|:.::.....|..:....|::|:....:.:.:|
Worm    70 VLVPTTDAINEIMGHAMKSGAVANLWTHSANSKQGIMWSTDMIGQVSYHNTKNLIDNKALVQQMK 134

  Fly   125 QNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLVGT------PSPPSYVPHSLL 183
            ..: ||..|.|.| :.:...|.|     :|.|.::.....||...||      |..||:||.|..
Worm   135 DEK-FDIGITELF-DFSGLAFFE-----VIGLKNVMGAHTTSVFEGTLMATGAPILPSFVPASQT 192

  Fly   184 RFGDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKYFPNNKQDFYRMRKDTSLVLLNNHVS 248
            ...|..:...|..||....:.:.::|.|.....:||...|........:.:..|.:...:|:...
Worm   193 FTDDSGSILSRLNNLYMTYWSYQFQNKIQSFAQKALDEHYEKGKAPKIWNLVSDITWFFVNSDPI 257

  Fly   249 ISNPRPYSPNMIEVGGMHVNRKAP--KPLPQNIRKFIEEAEHGVIYFSLGSNLNSKDLPENKRKA 311
            ...|:|...|::|:.|:.|    |  ||:.:...:.:.:....|: .|.||..:...:||..:|:
Worm   258 FDFPKPLPQNIVEIAGISV----PEIKPVGKEWDEILSKRSKNVL-VSFGSIASPTTMPEAVKKS 317

  Fly   312 IVETLRGL-KYRVIWKYE--EETFVDKPDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMESIY 373
            ||:..... ....||||:  |.......|||.|..|:||:|:||.:::..|.||||:.|.|||..
Worm   318 IVDAFAAFPDVTFIWKYDDTESKLTAHLDNVHIVKWMPQNDLLADKRISMFWTHGGMGSLMESAQ 382

  Fly   374 HGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFR---SAIERITSDPSFTERVKVISS 435
            ...|:|.:|.||||..|...|::  :|:.:.|.::..|..:   .|::.:..:|.:.:..::::.
Worm   383 KSVPLVVVPIFGDQMRNAQIAKR--HGVALIYDKMDLSNTKKLIGALKEVLENPEYKKSAELLAR 445

  Fly   436 QYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGLTVIFVFLLV 500
            ....::.:|.::.:..||...|........||.::.:|::|.|||::.....:..|:::...||:
Worm   446 ILATERFSPRQKIIDTVEMAGRFGQMPRWTSAGKEFSFLKYFNLDLVIIAVFIFFLSIVSTVLLI 510

  Fly   501 RFLV 504
            |.|:
Worm   511 RHLL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	91/363 (25%)
ugt-45	NP_500410.2	egt	14..513	CDD:223071	128/512 (25%)
ugt-45	NP_500410.2	UDPGT	19..510	CDD:278624	125/504 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14613
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810