DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302E1 and ugt-62

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_497918.1	Gene:	ugt-62 / 175591	WormBaseID:	WBGene00010904	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	550	Identity:	155/550 - (28%)
Similarity:	245/550 - (44%)	Gaps:	63/550 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLV--SPFPQRKPIKNIIDV 71
            :.|.|.|.|....|.|.:.....:.|....|..:|:.||..||:||::  |..|..|     .||
Worm     4 IALFLLLLGAVSAYKYAVFVPYMANSQVQFCTRVAEVLANGGHDVTMIHLSHLPDYK-----TDV 63

  Fly    72 ETPNIIT-------VMGVYKARILENAKKPVLLR-------------YPRISLMGLDITESLLKE 116
            :.|..|.       |.|:.|| :||..:...:.:             :.|...|..|...::::.
Worm    64 KIPKNIKVHRVEAYVEGLTKA-LLEKEQSAFIFKDTGLKDMPAMMSMFSRFGKMFQDGCRNIVRN 127

  Fly   117 PKVQELLKQNRTFDGVICETFMNDAHYGFAEHFGAP-LITLSSLGATGWTSDLVGTPSPPSYVPH 180
            .:..:.| :|..|| |......:....|.......| .:.|:|.....:.::.||.|..|||||.
Worm   128 KEFMKWL-ENEKFD-VAYSYIYSSCPIGLIHAAKIPSWVWLNSGALMDFVAETVGVPIIPSYVPP 190

  Fly   181 SLLRFGDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKYFPNNKQDFYR------------ 233
            .::...|.|.|:       |::..|....|:.:     |:|:...|.:...:|
Worm   191 LMMESDDEMGFF-------FRMKSFIGHTLMTV-----LHRRMTSNGETQIFRDELNDPNFPHTM 243

  Fly   234 -MRKDTSLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEAEHGVIYFSLGS 297
             :.....||::|::.....|||....::.:||:.|...:.|||....:| |.|...|:|.||.||
Worm   244 DLGAKCPLVIVNSNELYDLPRPTLAKVVNIGGLGVGFDSAKPLTGEFKK-ISETGKGMIVFSFGS 307

  Fly   298 NLNSKDLPENKRKAIVETLRGL-KYRVIWKYEEETFVDK-PDNVLISNWLPQDDILAHEKVIAFI 360
            ...:.|:|...:.:|:|....| .|:.:.:|..:...|: |.||.:..||||.|:|.|.|..|||
Worm   308 VAAAHDMPLEWKNSILEAFSSLPDYQFLMRYVADDLNDRLPKNVHLFKWLPQKDLLLHNKTKAFI 372

  Fly   361 THGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPS 425
            ||||..|..|:|..|.|:|.|..||||..|...|::.|:.:.::..:::......||..|..:.|
Worm   373 THGGYNSMQEAISAGVPLVTIALFGDQPKNSKVAKKHGFAVNIQKGEISKKTIVKAIMEIVENDS 437

  Fly   426 FTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIG 490
            :.::|..:|:..|.|...|.||.:.|.|.:...|....|..|.|.|||.|||:|||:...|.||
Worm   438 YKQKVSRLSAMVRAQPMKPAERLLKWSEFLAEFKTLDNLEPAGQKLNFFQYHSLDVITFLFIVI- 501

  Fly   491 LTVIFVFLLVRFLVTIVN-GFLYKPSSKLK 519
              .|..::..||:..::. .|..|..:|.|
Worm   502 --FIVFYIGYRFMRAVIRCCFCKKCETKTK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	102/365 (28%)
ugt-62	NP_497918.1	UDPGT	37..520	CDD:278624	143/506 (28%)
ugt-62	NP_497918.1	egt	<251..471	CDD:223071	74/220 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14329
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3869
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840