DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and ugt-28

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_491437.1	Gene:	ugt-28 / 172086	WormBaseID:	WBGene00015693	Length:	537	Species:	Caenorhabditis elegans

Alignment Length:	552	Identity:	141/552 - (25%)
Similarity:	233/552 - (42%)	Gaps:	75/552 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPF--PQR-------KPI 65
            |:..:.|..:...:.|:.|...:.||......||..|...||.||.:.|.  |::       |..
Worm     6 LIFSSFFCSTSSLNILVYSPAFAASHSNFLGKLADTLTERGHNVTYLMPVVDPEKRDECIGVKLT 70

  Fly    66 KNIIDVE------------TPNIITVMGVYKARILENAKKPVLLRYPRISLMGLDITESLLKEPK 118
            |:::.||            |||...:...:|:.:..:..:.:      .|....|:..:.....|
Worm    71 KDLVIVEPDEEMMSFKKGSTPNGEIMELFWKSEMDSSNSRDM------FSFFNSDMKLACRNFHK 129

  Fly   119 VQELLKQ--NRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTS--DLVGTPSPPSYVP 179
            .:::.:|  :|.||..|.|. :.....||.:..|.....|:| .:|.:.:  |.:|.|...||||
Worm   130 RRDIFEQMKSRNFDVAILEP-VTICGLGFVKALGIEKTILAS-SSTFYDAVMDYIGEPLDYSYVP 192

  Fly   180 HSLLRFGDRMNFWERAQNLGFQIYEFAYENL-----INLPRHEAL------YRKYFPNNKQDFYR 233
            ......||.|...||            |||.     ||:..|:..      ||::...:..::..
Worm   193 SGFSVTGDVMTMAER------------YENWMVVKEINIALHDMFDGEMKSYREFLGEDLPNWRE 245

  Fly   234 MRKDTSLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIE---EAEHGVIYFSL 295
            :....|:..:|.:..:..||......:.:||:.:|.|..|  .|.:.|..|   |.....:..|.
Worm   246 LLSSASIFFVNANPFLDFPRAVLQKTVPIGGISINLKWIK--EQKLTKDWEDILEKRTKTVLISF 308

  Fly   296 GSNLNSKDLPENKRKAIVETLRGL-KYRVIWKYE--EETFVDKPDNVLISNWLPQDDILAHEKVI 357
            ||.:.|..:|:..|..::|.::.: ....|:|||  |.:|.|...|:..|.|:||..:|...::.
Worm   309 GSMVKSAYMPKIWRNGLLEVIKSMPDVTFIFKYESDEVSFADGISNIHFSKWVPQTALLNDPRLS 373

  Fly   358 AFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMAR--AEQMGYGITVKYAQLTASLFRSAIERI 420
            ||:|||||.||||..|.|||.|.||.|.||..| ||  |...|.....|.:.....:.|.|:..:
Worm   374 AFVTHGGLGSTMELAYSGKPGVVIPVFADQIRN-ARMIARHNGVIYLHKNSMENVKVTRKALTDV 437

  Fly   421 TSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATF 485
            ..|.|:.:..:.::....:|..:|:|..:.:.|.|..|..........:.||:.|       .||
Worm   438 LYDESYKKNAEKLTDILMNQPYSPMENVIKYTEFVGEHGPFPNTDPYGRHLNYFQ-------KTF 495

  Fly   486 FSVIGLTVIFVFLLVRFLVTIVNGFLYKPSSK 517
            |.:..|..:| ::.|..::.|...|:|:.:.|
Worm   496 FDIYALFALF-YISVGTIIAISIRFIYQKARK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	103/372 (28%)
ugt-28	NP_491437.1	UDPGT	40..536	CDD:278624	133/518 (26%)
ugt-28	NP_491437.1	egt	<193..472	CDD:223071	81/293 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810