DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302E1 and UGT3A2

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_011512290.1	Gene:	UGT3A2 / 167127	HGNCID:	27266	Length:	550	Species:	Homo sapiens

Alignment Length:	527	Identity:	153/527 - (29%)
Similarity:	231/527 - (43%)	Gaps:	80/527 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 QSWGYSYLMISH------------TASKSHYAVCFALAK----GLAAAGHE------VTLVSPFP 60
            |..|::..|::|            .||.|.|.....|.|    ||.....|      ::.::|..
Human    47 QDHGHNVTMLNHKRGPFMPGLSDSPASASRYPRILYLQKYCQFGLKDFKKEEKSYQVISWLAPED 111

  Fly    61 QRKPIKNIIDVETPNIITVMGVYKARILENAKKPVLLRYPRISLMGLDITESLLKEPKVQELLKQ 125
            .::..|...|.....  |:.|..|...|.|..:.:.|:.... |...||.:||           :
Human   112 HQREFKKSFDFFLEE--TLGGRGKFENLLNVLEYLALQCSHF-LNRKDIMDSL-----------K 162

  Fly   126 NRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLVGTPSPPSYVP--HSLLRFGDR 188
            |..||.||.||| :...:..||..|.|.:.:.|   |.:.|...|.|.|.||||  .|||.  |.
Human   163 NENFDMVIVETF-DYCPFLIAEKLGKPFVAILS---TSFGSLEFGLPIPLSYVPVFRSLLT--DH 221

  Fly   189 MNFWERAQNLGFQIYEFAYENLINLPRHEALYRKYFPNNKQDFY---------RMRKDTSLVLLN 244
            |:||.|.:|. ...:.|.        |.:...:..|.|..::.:         .:.....|..:|
Human   222 MDFWGRVKNF-LMFFSFC--------RRQQHMQSTFDNTIKEHFTEGSRPVLSHLLLKAELWFIN 277

  Fly   245 NHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEE-AEHGVIYFSLGSNLNSKDLPE-- 306
            :..:....||..||.:.|||:  ..|..||:||::..||.: .:.|.:..:|||.:|:...||
Human   278 SDFAFDFARPLLPNTVYVGGL--MEKPIKPVPQDLENFIAKFGDSGFVLVTLGSMVNTCQNPEIF 340

  Fly   307 -NKRKAIVETLRGLKYRVIWKYEEETF---VDKPDNVLISNWLPQDDILAHEKVIAFITHGGLLS 367
             ....|.....:|    ||||.:...:   |....||.|.:||||.|:|||..:..|:||||..|
Human   341 KEMNNAFAHLPQG----VIWKCQCSHWPKDVHLAANVKIVDWLPQSDLLAHPSIRLFVTHGGQNS 401

  Fly   368 TMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTERVKV 432
            .||:|.||.|:||||.||||..||.|.|...:|::::..:|.|......:::|..|..:......
Human   402 IMEAIQHGVPMVGIPLFGDQPENMVRVEAKKFGVSIQLKKLKAETLALKMKQIMEDKRYKSAAVA 466

  Fly   433 ISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQ-YHNLDVLATFFSVIGLTVIFV 496
            .|...|....:|.:|.|.|::||.:..||.:|:...    |.| :|...:|..|..::|||:..:
Human   467 ASVILRSHPLSPTQRLVGWIDHVLQTGGATHLKPYV----FQQPWHEQYLLDVFVFLLGLTLGTL 527

  Fly   497 FLLVRFL 503
            :|..:.|
Human   528 WLCGKLL 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	115/367 (31%)
UGT3A2	XP_011512290.1	UDPGT	23..518	CDD:278624	148/509 (29%)
UGT3A2	XP_011512290.1	egt	<162..517	CDD:223071	120/379 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150558
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3869
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.770