DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_569091.2	Gene:	Ugt1a7c / 154516	RGDID:	620950	Length:	531	Species:	Rattus norvegicus

Alignment Length:	507	Identity:	162/507 - (31%)
Similarity:	253/507 - (49%)	Gaps:	36/507 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSP---FPQRKPIKNIID 70
            |.|:||   ..:|::..::......||:.....:.:.|...||||.:|.|   :...||:.  ..
  Rat    14 LCLLLA---SGFGHAGKLLVVPMDGSHWFTMQMVVEKLLPKGHEVVVVVPEVSWQLGKPLN--FT 73

  Fly    71 VETPNI------------ITVMGVYKARILENAKKPVLLRYPRISLMGLDIT--ESLLKEPKVQE 121
            |:|.::            ..:...:|.: .|....| ||..|......|..:  .||.|:.|:.|
  Rat    74 VKTYSVSHTQEDLNREFKFFIDSQWKTQ-QEGGVLP-LLTSPAQGFFELLFSHCRSLFKDKKLVE 136

  Fly   122 LLKQNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLVGTPSPPSYVPHSLLRFG 186
            .|||: :||.|..:.| :......|::|..|.:..|......:..:....||||||||..:|:..
  Rat   137 YLKQS-SFDAVFLDPF-DVCGLTVAKYFSLPSVVFSRGIFCHYLEEGSQCPSPPSYVPRGILKLT 199

  Fly   187 DRMNFWERAQNLGFQIYEFAY-ENLINLPRHEALYRKYFPNNKQDFYRMRKDTSLVLLNNHVSIS 250
            |.|.|.||..||...:.|.|: .:........|......|....|.:   ...|:.||....::.
  Rat   200 DTMTFKERVWNLLSYMGEHAFCPSFFKTATDIASEVLQTPVTMTDLF---SPVSVWLLRTDFTLE 261

  Fly   251 NPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIE-EAEHGVIYFSLGSNLNSKDLPENKRKAIVE 314
            .|||..||:|.:||::.:::  |||.:....::. ..|||::.|||||.::  ::||.|...|.|
  Rat   262 LPRPVMPNVIHIGGINCHQR--KPLSKEFEAYVNASGEHGIVVFSLGSMVS--EIPEKKAMEIAE 322

  Fly   315 TLRGLKYRVIWKYEEETFVDKPDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMESIYHGKPVV 379
            .|..:...|:|:|......:...|.::..||||:|:|.|.|..|||||.|.....|.|.:|.|:|
  Rat   323 ALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMV 387

  Fly   380 GIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTERVKVISSQYRDQKETP 444
            .:|.||||..|..|.|..|.|:|:...::||....:|::.:.::.|:.|.:..:||.::|:...|
  Rat   388 MMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEP 452

  Fly   445 LERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGLTVIFV 496
            |:.||:|||:|.|||||.:||.|..||.:.|||:|||:. |...|.|||:|:
  Rat   453 LDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIG-FLLAIVLTVVFI 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	118/351 (34%)
Ugt1a7c	NP_569091.2	UDPGT	26..522	CDD:278624	157/492 (32%)
Ugt1a7c	NP_569091.2	egt	<264..505	CDD:223071	96/245 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H136043
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.860