DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and Ugt2b37

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_444445.2	Gene:	Ugt2b37 / 112417	MGIID:	2148239	Length:	530	Species:	Mus musculus

Alignment Length:	528	Identity:	154/528 - (29%)
Similarity:	263/528 - (49%)	Gaps:	75/528 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SHYAVCFALAKGLAAAGHEVTLVSPF------PQRKPIKNIIDVET-PNIIT----------VMG 81
            ||:.....:...|...|||||::.|.      |::.|   .:..|| |..:|          ::.
Mouse    34 SHWMNIKIILDELVQRGHEVTVLRPSAYYVLDPKKSP---GLKFETFPTSVTKDDLENFFIQLLN 95

  Fly    82 VYKARILEN---AKKPVLLR-YPRISLMGLDITESLLKEPKVQELLKQNRTFDGVICETFMNDAH 142
            |:...:..:   :..|::.. :..:|...|.:.:.::...::...|:::: ||.::.:.
Mouse    96 VWTYELSRDTCLSYSPLMQNMFDELSGYYLSLCKDVVSNRQLMTKLQESK-FDVLLSDP------ 153

  Fly   143 YGFAEHFGAPLITLSSLGATGWTSDLVGTPS------PPSYVPHSLLRFGDRMNFWERAQNLGFQ 201
            ..|.....|.|:.:..|.:..:|:......|      ||||||..|...|.:|.|.||.:|:...
Mouse   154 VAFGGELIAELLHIPFLYSLRFTAGYRIEKSSGRFLLPPSYVPVILSGLGGQMTFIERVKNMICM 218

  Fly   202 IY-EFAYENLINLPRHEALYRKYFPNNKQ--DFYR--MRKDTSLV---------LLNNHVSISNP 252
            :| :|.::               .||:|:  .||.  :.:.|:|.         |:.::..:..|
Mouse   219 LYFDFWFQ---------------MPNDKKWDSFYTEYLGRPTTLAETMGQAEMWLIRSNWDLEFP 268

  Fly   253 RPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEA-EHGVIYFSLGSNLNSKDLPENKRKAIVETL 316
            .|..||:..|||:|.  |..||||:::.::::.: :|||:.|||||.::  ::.|.|..||...|
Mouse   269 HPTLPNVDYVGGLHC--KPAKPLPKDMEEYVQSSGDHGVVVFSLGSMVS--NITEEKVNAIAWAL 329

  Fly   317 RGLKYRVIWKYEEETFVDKPDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMESIYHGKPVVGI 381
            ..:..:|:||::.:|......|..:..||||:|:|.|.|..|||||||..|..|:||||.|::||
Mouse   330 AQIPQKVLWKFDGKTPATLGHNTRVYKWLPQNDLLGHPKTKAFITHGGANSVYEAIYHGIPMIGI 394

  Fly   382 PFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTERVKVISSQYRDQKETPLE 446
            |.||:|..|:|.....|..:|:....::.|...:|:|.:..:|.:.:....:|:.:.||...||:
Mouse   395 PLFGEQHDNIAHMVAKGAAVTLNIRTMSRSDVLNALEEVIENPFYKKNAMWLSTIHHDQPMKPLD 459

  Fly   447 RAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGLTVIFVFLLVRFLVTIVNGFL 511
            |||:|||.|.|||.||:||....:|.:.|||:|||:....:.:..||:   |.|:.|:.|...|:
Mouse   460 RAVFWVEFVMRHKNAKHLRPLGHNLTWYQYHSLDVIGFLLACVAATVV---LTVKCLLFIYRFFV 521

  Fly   512 YKPSSKLK 519
            .| ..|:|
Mouse   522 TK-KKKMK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	116/370 (31%)
Ugt2b37	NP_444445.2	UDPGT	24..527	CDD:278624	152/525 (29%)
		Glycosyltransferase_GTB_type	42..>174	CDD:299143	24/141 (17%)
		egt	<270..489	CDD:223071	86/222 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840482
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690