Protein Alignment Ugt302E1 and UGT2A1

DIOPT Version :9

• Sequence 1: NP_652625.2
• Gene: Ugt302E1 / 53508
• FlyBaseID: FBgn0040257
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 157/516 - (30%)
• Similarity: 245/516 - (47%)
• Gaps: 61/516 - (11%)

  Fly    18 QSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTL--------------------VSPFPQR 62
            :||...|   |.....||:.....:.:.|....|.||:                    |.|...:
Human   228 KSWDSYY---SKALDGSHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYK 289

  Fly    63 KP-IKNIID-------VETPNIITVMGVYK--ARILENAKKPVLLRYPRISLMGLDITESLLKEP 117
            |. |.::|:       ...|..:|:...||  .::|:.           ...:.:.:.:.:||.|
Human   290 KSNIDSLIEHMIMLWIDHRPTPLTIWAFYKELGKLLDT-----------FFQINIQLCDGVLKNP 343

  Fly   118 KVQELLKQNRTFDGVICE--TFMNDAHYGFAEHFGAP-LITLSSLGATGWTSDLVGTPSPPSYVP 179
            |:...| |...||.::.:  |...|.   .|...|.| :.||....|:.........|:|.||||
Human   344 KLMARL-QKGGFDVLVADPVTICGDL---VALKLGIPFMYTLRFSPASTVERHCGKIPAPVSYVP 404

  Fly   180 HSLLRFGDRMNFWERAQN-LGFQIYEFAYENLINLPRHEALYRKYFPNNKQDFYRMRKDTSLVLL 243
            .:|....|:|.|.||.:| :.:.:.::.:::...  ...:.|.|...........|.| ..:.|:
Human   405 AALSELTDQMTFGERIKNTISYSLQDYIFQSYWG--EWNSYYSKILGRPTTLCETMGK-AEIWLI 466

  Fly   244 NNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEA-EHGVIYFSLGSNLNSKDLPEN 307
            ..:.....||||.||...|||:|.  |..||||:.:.:||:.: ::||:.|||||.:  |:|.|.
Human   467 RTYWDFEFPRPYLPNFEFVGGLHC--KPAKPLPKEMEEFIQSSGKNGVVVFSLGSMV--KNLTEE 527

  Fly   308 KRKAIVETLRGLKYRVIWKYEEETFVDKPDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMESI 372
            |...|...|..:..:|:|:|:.:......:|..:.:|:||:|:|.|.|..|||||||.....|:|
Human   528 KANLIASALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAI 592

  Fly   373 YHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTERVKVISSQY 437
            |||.|:||:|.|.||..|:|..:..|..:.|....:|:....||:..:.::||:.|....:|..:
Human   593 YHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIH 657

  Fly   438 RDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGLTVIFVFL 498
            .||...||:|||:|:|.|.||||||:||.|..||.:.|||:|||:. |..|...|.||:.:
Human   658 HDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIG-FLLVCVTTAIFLVI 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	121/354 (34%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	153/504 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150207
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.690