DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302E1 and Ugt2b38

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_598655.1	Gene:	Ugt2b38 / 100559	MGIID:	2140794	Length:	530	Species:	Mus musculus

Alignment Length:	549	Identity:	157/549 - (28%)
Similarity:	250/549 - (45%)	Gaps:	117/549 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SHYAVCFALAKGLAAAGHEVTLVSPF------PQRKP---------------IKN----IIDV-- 71
            ||:.....:...|...|||||::.|.      |::.|               ::|    .:||
Mouse    34 SHWMNIKIILDELVQRGHEVTVLRPSAYYVLDPKKSPGLKFETFPTSVSKDNLENFFIKFVDVWT 98

  Fly    72 -ETP------------NIITVMGVYKARI-------------LENAKKPVLLRYPRISLMGLDIT 110
             |.|            |:|.....|...:             |:.:|..|||..| ::..| ::.
Mouse    99 YEMPRDTCLSYSPLLQNMIDEFSDYFLSLCKDVVSNKELMTKLQESKFDVLLSDP-VASCG-ELI 161

  Fly   111 ESLLKEPKVQELLKQNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLVGTPSPP 175
            ..||:.|    .|...|...|           |...:..|..|:                   ||
Mouse   162 AELLQIP----FLYSIRFSPG-----------YQIEKSSGRFLL-------------------PP 192

  Fly   176 SYVPHSLLRFGDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKYFPNNKQDFYRMRKDTSL 240
            ||||..|...|.:|.|.||.:|:..::|...:..:.|..:.::.|.:|          :.:.|:|
Mouse   193 SYVPVILSGLGGQMTFIERVKNMICRLYFDFWFQMFNDKKWDSFYSEY----------LGRPTTL 247

  Fly   241 V---------LLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEA-EHGVIYFSL 295
            .         |:.::..:..|.|..||:..|||:|.  |..||||:::.:|::.: :|||:.|||
Mouse   248 AETMGKAEMWLIRSNWDLEFPHPTLPNVDYVGGLHC--KPAKPLPKDMEEFVQSSGDHGVVVFSL 310

  Fly   296 GSNLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKPDNVLISNWLPQDDILAHEKVIAFI 360
            ||.::  ::.|.|...|...|..:..:|:||::.:|......|..:..||||:|:|.|.|..||:
Mouse   311 GSMVS--NMTEEKANTIAWALAQIPQKVLWKFDGKTPATLGHNTRVYKWLPQNDLLGHPKTKAFV 373

  Fly   361 THGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPS 425
            ||||.....|.||||.|::|||.||:|..|:|.....|..:|:....::.|...:|:|.:..:|.
Mouse   374 THGGANGVYEVIYHGIPMIGIPLFGEQHDNIAHMVAKGAAVTLNIRTMSRSDVLNALEEVIDNPF 438

  Fly   426 FTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIG 490
            :.:....:|:.:.||...||:|||:|||.|.|||.||:|||...:|.:.|||.|||:....|.:.
Mouse   439 YKKNAIWLSTIHHDQPTKPLDRAVFWVEFVMRHKRAKHLRSLGHNLTWHQYHFLDVIGFLLSCVA 503

  Fly   491 LTVIFVFLLVRFLVTIVNGFLYKPSSKLK 519
            :|::   |.|:.|:.|.. |..|...|:|
Mouse   504 VTIV---LTVKCLLFIYR-FFVKKEKKIK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	110/359 (31%)
Ugt2b38	NP_598655.1	egt	8..506	CDD:223071	148/521 (28%)
Ugt2b38	NP_598655.1	UDPGT	24..526	CDD:278624	155/545 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840481
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690