DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302E1 and ugt5a4

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001170969.2	Gene:	ugt5a4 / 100415798	ZFINID:	ZDB-GENE-100406-1	Length:	525	Species:	Danio rerio

Alignment Length:	540	Identity:	170/540 - (31%)
Similarity:	254/540 - (47%)	Gaps:	82/540 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSP-----FPQRKPIKNI 68
            |.|:|.:..:|.....|::  ....||:.....|...|.:.||.:|:|..     ..::.|:...
Zfish    10 LFLLLCVLSRSHAGKLLVV--PVDGSHWINMKVLLVELHSKGHSITVVRASNSWYIEEQSPLYTS 72

  Fly    69 IDVETPNIITVMGVYKARILENAKKPVLLRYPR------ISLMGLDITESLLKEPKVQELLKQNR 127
            |.||.       |.:.|...|.. .|.||:..|      ..:...|.|.|...|.. ||:.|...
Zfish    73 ITVEN-------GEFDADFGEKF-LPHLLKMQRQGKSFWTEMALADETYSRFTEIH-QEICKMTA 128

  Fly   128 T-FDGVICETFMN---DAHYG-------------FAEHFGAPLITLSSLGATGWT----SDLVGT 171
            | |:.   ||.||   ||.|.             .|...|.||:.     ...||    :..|..
Zfish   129 TMFEN---ETLMNSLKDAAYDVVLTDPAFGGGVLLAHRLGLPLVF-----NVRWTMYGEAHFVIA 185

  Fly   172 PSPPSYVPHSLLRFGDRMNFWERAQNLGFQIYEFAYEN--LINLPRHEALYRKYF-PNNKQDFYR 233
            |||.||||.|.|:..|:|.|.:|..|:...|. ..|:|  ....| ::.|.:||| ||  .:|:.
Zfish   186 PSPLSYVPVSGLQLTDKMTFSQRVMNMMTYIM-ILYKNSKYFGSP-YQELTQKYFGPN--VNFFS 246

  Fly   234 MRKDTSLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEA-EHGVIYFSLG- 296
            :.:|..|.|:.|..:...|||..||::.:||...  |..||||.::.:|::.: |||||..|||
Zfish   247 LLQDADLWLMRNDFTFEFPRPTMPNVVYMGGFQC--KPAKPLPGDLEEFVQSSGEHGVIMMSLGA 309

  Fly   297 ------SNLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKPDNVLISNWLPQDDILAHEK 355
                  |.||.:         |......|..:|||:|......:..:|.||.|||||:|:|.|.|
Zfish   310 VFGQLLSELNDE---------IAAAFAQLPQKVIWRYTGPRPANLGNNSLIVNWLPQNDLLGHPK 365

  Fly   356 VIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERI 420
            ...|:.|||.....|:||||.|:||:|...||..|::|....|....|..|.|..::|..|::.:
Zfish   366 TKLFVAHGGTNGLQEAIYHGVPIVGLPLAFDQPDNLSRMRAKGTAKIVDIATLDRAVFLEALKEV 430

  Fly   421 TSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATF 485
            ..:||:.|.::.:|..:.||...||:||::|:|.|.|:|||.:||:....:::|:|.::||:.|.
Zfish   431 LHNPSYRENMQRLSKLHHDQPMKPLDRAIFWIEFVMRNKGAPHLRTQSFRMSWIEYQSIDVILTL 495

  Fly   486 FSVIGLTVIFVFLLVRFLVT 505
                 :.::.||.||...:|
Zfish   496 -----MVMVLVFALVTAYMT 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	131/381 (34%)
ugt5a4	NP_001170969.2	UDPGT	23..525	CDD:278624	166/527 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000