DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and ugt5c1

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001170966.1	Gene:	ugt5c1 / 100415793	ZFINID:	ZDB-GENE-050419-68	Length:	531	Species:	Danio rerio

Alignment Length:	538	Identity:	154/538 - (28%)
Similarity:	261/538 - (48%)	Gaps:	74/538 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WLLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPIKNIIDVE 72
            | :.::.:||.......:::: ....||:.....|.|.|...||.|.::     |......:...
Zfish    14 W-ITVMIIFGSLCDGGKILVA-PLEGSHWVNMDILIKALHGQGHTVDVI-----RNTNSWFVKEN 71

  Fly    73 TP--NIITV---MGVYKARILENAKKPVLLRYPRISLMG-----LDITESLLKEPKV-------- 119
            :.  |.||:   .|:.:..:.:...|.:.....:.|.:|     ||:::::.:..|:
Zfish    72 STYYNSITIPDSKGMDEEFVEDVLTKKIDYERGKGSWLGGVQLFLDVSKAVYESHKLVCRLITNI 136

  Fly   120 ---QELLK--QNRTFDGVICETFMNDAHYG----FAEHFGAPLITLSSLGATGWTSDLVG----T 171
               :::||  |.:.:|     ..:.|..:|    .|.....|::.     ...||:...|    .
Zfish   137 FESEDILKALQEKKYD-----LMLTDPGWGTGIILAHKLKLPMVY-----NVRWTTPGEGHFDIA 191

  Fly   172 PSPPSYVPHSLLRFGDRMNFWERAQN------LGFQIYEFAYENLINLPRHEALYRKYFPNNKQD 230
            |||.||:|.:.....|:|:|::|..|      |.||...|      |:|:::||..||| :...|
Zfish   192 PSPMSYIPLTGSGNTDKMSFFQRVINVFYYLLLDFQCSRF------NVPQYQALCDKYF-DPPVD 249

  Fly   231 FYRMRKDTSLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEA-EHGVIYFS 294
            ||::.:...|.|:........|||..||:|..||....  ..||||.::..|::.: :||||..|
Zfish   250 FYKLLQGADLWLMRVDFVFEFPRPTMPNIIYTGGFQCT--PTKPLPHDLEDFMQSSGDHGVIVMS 312

  Fly   295 LGSNLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKP----DNVLISNWLPQDDILAHEK 355
            |||.::.  ||:.....|......|..:|||:|..:    ||    :|.|:.:|:||.|:|.|.|
Zfish   313 LGSFISV--LPDYVSSEIAAAFARLPQKVIWRYTGK----KPSTLGNNTLLVDWMPQKDLLGHPK 371

  Fly   356 VIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERI 420
            ...||.|||.....|::|||.||:|||||.||:.|:.|.:..|....|..|:|..:...:||:.:
Zfish   372 TKLFIAHGGTNGVQEALYHGVPVIGIPFFFDQYDNLIRLQARGGAKIVSLAELGENSLHAAIQEV 436

  Fly   421 TSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATF 485
            .::||:...::.:|..:||:...||:.|::|:|.|.|||||.:||:....:.:..||::||..|.
Zfish   437 INEPSYRLNMQKLSYLHRDKPVEPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVSVTL 501

  Fly   486 FSVIGLTVIFVFLLVRFL 503
            .:|:.:.:..:|:.||:|
Zfish   502 IAVVLIFIYSMFVTVRYL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	121/381 (32%)
ugt5c1	NP_001170966.1	UDPGT	28..530	CDD:278624	151/523 (29%)
ugt5c1	NP_001170966.1	egt	<267..507	CDD:223071	90/247 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585108
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690