DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and ugt5b3

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001348442.1	Gene:	ugt5b3 / 100415792	ZFINID:	ZDB-GENE-100406-5	Length:	534	Species:	Danio rerio

Alignment Length:	540	Identity:	143/540 - (26%)
Similarity:	258/540 - (47%)	Gaps:	69/540 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRWLLNSWLLLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPI 65
            |||.:...|||:.....:|..    ::......||:.....|.:.|.|.||.:|::     |...
Zfish     8 MRWPVTLTLLLVTVPVVESGN----VLVFPVDVSHWVNMNVLVEALHAKGHNITVM-----RMAD 63

  Fly    66 KNIIDVETPNIITV------------MGVYKARILENAKKPVLLR----YPRISL---------- 104
            ...|...:|:..:|            :|.:.:|::.      :||    :.|:.|
Zfish    64 SWYIKEFSPHYTSVNLKSSGGLSEDFIGPFVSRLMN------ILREGSTWGRLKLEIEMWQTSLK 122

  Fly   105 ---MGLDITESLLKEPKVQELLKQNRTFDGVICETFMNDAHYG--FAEHFGAPLITLSSLGATGW 164
               :..::..:::::.::.:.||:.: ||.::.:..|    ||  ...|:    :.|..:....|
Zfish   123 MIEIEREMITNMIEDQQLMQSLKKAK-FDLILTDPAM----YGGVMLGHY----LKLPIVYNVRW 178

  Fly   165 TSDLVG------TPSPPSYVPHSLLRFGDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKY 223
            |  :.|      .|||.||||..:|...|||:|.||.:|:...|........:..|.:.||..:
Zfish   179 T--IFGEGHFAIAPSPLSYVPVPMLEIPDRMSFLERVKNVVMYIITETQIAFLIAPTYNALCER- 240

  Fly   224 FPNNKQDFYRMRKDTSLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEA-E 287
            |...:.:|..:.::..|.|.........|||..||::.:.|...  |..|||||::..|::.: :
Zfish   241 FIGPEVNFGNLVQEADLWLHRADFVFEYPRPTMPNIVYMAGFQC--KPSKPLPQDLEDFVQSSGD 303

  Fly   288 HGVIYFSLGSNLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKPDNVLISNWLPQDDILA 352
            ||||..|||:.:.  .||::..:||.|....|..::||:|:.:......:|.|:.:|:||:|:|.
Zfish   304 HGVIVMSLGTLIG--QLPDDVAEAIAEAFAELPQKIIWRYKGKRPSALGNNTLVMDWMPQNDLLG 366

  Fly   353 HEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAI 417
            |.|..||:.|||.....|:||||.|::|.....||..|:::....|....|.:|.:....|...:
Zfish   367 HPKTRAFVAHGGTNGVQEAIYHGVPIIGFGLIFDQPDNLSKMRVRGAAKNVDFATMDKESFLKTV 431

  Fly   418 ERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVL 482
            :.:..|||:.|.::.:|..::|....||:.|::|:|.|.|||||.:||:....:.:..||::||:
Zfish   432 KEVLYDPSYRENMQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVI 496

  Fly   483 ATFFSVIGLTVIFVFLLVRF 502
            ....|.:.|.::.::.::|:
Zfish   497 LVLISAVSLIILSIYAVIRY 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	109/358 (30%)
ugt5b3	NP_001348442.1	UDPGT	27..531	CDD:278624	136/521 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584543
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790