DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302E1 and ugt2b3

DIOPT Version :9

Sequence 1:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001170812.2	Gene:	ugt2b3 / 100384898	ZFINID:	ZDB-GENE-100402-2	Length:	527	Species:	Danio rerio

Alignment Length:	542	Identity:	150/542 - (27%)
Similarity:	247/542 - (45%)	Gaps:	83/542 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLILALF--GQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSP----FPQRKPIK-- 66
            |.:|.:|  ||.   ..:::.||.. ||:.....:...|...||.||::.|    |.:.|...
Zfish     8 LSLLTVFSAGQC---GNILVWHTEG-SHWINLKIVLDTLLDRGHNVTVLMPDGALFMKAKESDRF 68

  Fly    67 ------------------------NIIDVETPNIITVMGVYKARILENAKKPVLLRY----PRIS 103
                                    ::.::|..|::.:.                :::    .|..
Zfish    69 SYQNFSVSTSAQDMQDFLDELLHFSVFEMEQLNLLQIQ----------------MKFFDLGSRHQ 117

  Fly   104 LMGLDITESLLKEPKVQELLKQNRTFDGVICETFMNDAHYG----FAEHFGAPLITLSSLGATGW 164
            .|||...:.:||.|::.:.||..: ||     ..::|..|.    .||....||:..........
Zfish   118 DMGLSYCDGILKSPELMDKLKTGK-FD-----VLLSDPMYPCSDIVAEVLNVPLVFTLRFSIAHT 176

  Fly   165 TSDLVG-TPSPPSYVPHSLLRFGDRMNFWERAQNLGFQIYEFAYENLINLPRHEALYRKYFPNNK 228
            ...:.| .|:||||||.::.:..|:|:|.||..|..|.:....: ::|...:.:..|.:|| ...
Zfish   177 MERICGQIPAPPSYVPGAMSKLTDKMSFTERIFNTLFYLSMDTF-SIIAWKKFDNYYTEYF-GRP 239

  Fly   229 QDFYRMRKDTSLVLLNNHVSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEA-EHGVIY 292
            ..:..|.....:.|:..:.....|||:.||...:||:|..  ..||||:::.:|::.: :.|::.
Zfish   240 TSYCEMMGRADIWLIRTYWDFEFPRPFVPNFKYIGGLHCT--PAKPLPKDMEEFVQSSGDDGIVV 302

  Fly   293 FSLGSNLNSKDLPENKRKAIVETLRGLKYRVIWKYEEETFVDKPD----NVLISNWLPQDDILAH 353
            |:|||.::.  :|:.....|...|..:..:|:|:|..|    |||    |..|..|:||:|:|.|
Zfish   303 FTLGSMIDK--VPKEMSNRIASALAQIPQKVLWRYGGE----KPDTLGENTRIYKWMPQNDLLGH 361

  Fly   354 EKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFMNMARAEQMGYGITV-KYAQLTASLFRSAI 417
            .|..|||||||.....|:||||.|:||||.||||..||......|..:.| ....:........:
Zfish   362 PKTRAFITHGGTNGIYEAIYHGVPMVGIPLFGDQPDNMVHMTTRGAAVVVDSIKSMQPQELVDKL 426

  Fly   418 ERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVL 482
            ..:.:|||:.|....:|..:.|:...||:.:|:|:|.|.|:||||:||....:|.:.|||.|||.
Zfish   427 NTVINDPSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQYHCLDVF 491

  Fly   483 ATFFSVIGLTVIFVFLLVRFLV 504
            |...:|:.|.:...|.:.:|.:
Zfish   492 AFLTTVLTLVLYICFKMAKFFI 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	113/360 (31%)
ugt2b3	NP_001170812.2	UDPGT	20..523	CDD:278624	145/527 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584929
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690