Protein Alignment Ugt35C1 and UGT2B4

DIOPT Version :10

• Sequence 1: NP_001097744.1
• Gene: Ugt35C1 / 53507
• FlyBaseID: FBgn0040256
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_066962.2
• Gene: UGT2B4 / 7363
• HGNCID: 12553
• Length: 528
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 160/552 - (28%)
• Similarity: 264/552 - (47%)
• Gaps: 85/552 - (15%)

  Fly     8 AIVFCALSAKPLESESAKILATLPFPGR-SQYIFVESYLKALAAKGHQVTVIN-----AFKNKET 66
            |::...||.........|:|.   :|.. |.::.:::.|..|..:||:|||:.     :|.....
Human     8 ALLLIQLSCYFSSGSCGKVLV---WPTEFSHWMNIKTILDELVQRGHEVTVLASSASISFDPNSP 69

  Fly    67 PNMRF---IEALKAHEFADEMMSLL----NVP-------------LLWQQLNAMDYILNKFI-DV 110
            ..::|   ..:|...||.|.:..|:    .:|             ::|    ..:.||.||. |:
Human    70 STLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMW----TFNDILRKFCKDI 130

  Fly   111 TMEDEGVQRLLNSGETFDLVLAE-------------------MLHMEPMYAFAQHFNATLVGFSS 156
            ....:.:::|..|  .||:|||:                   .|...|.||..:|
Human   131 VSNKKLMKKLQES--RFDVVLADAVFPFGELLAELLKIPFVYSLRFSPGYAIEKH---------- 183

  Fly   157 FGTDRTIDEAAGNISPISYNPLVTSPRTDRMTFLERLENHYEVIVEDIHRHFVHLPHMRNVYKKY 221
                     :.|.:.|.||.|:|.|..:|:|||:||::|...|:..:.......:......|.:.
Human   184 ---------SGGLLFPPSYVPVVMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQFYSEV 239

  Fly   222 FPNAKKTLEEVMDSFSLILLGQHFSLSYPRPYLPNMIEVGGMHISHKP-KPLPEDIKQFIEGS-P 284
            . ....||.|.|....:.|:..::...:|.|.|||:..|||:|.  || ||||:::::|::.| .
Human   240 L-GRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHC--KPAKPLPKEMEEFVQSSGE 301

  Fly   285 HGVIYFSMGSNVKSKDLPQETRDTLLKTFAKLKQRVLWKFEDDDMPGKPANVLIKKWYPQPDILA 349
            :||:.||:||.|.:..  :|..:.:....||:.|:|||:|:.:.......|..:.||.||.|:|.
Human   302 NGVVVFSLGSMVSNTS--EERANVIASALAKIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLG 364

  Fly   350 HPNVKLFISHGGLLSSTESVYFGKPILGLPCFYDQHMNVQRAQRVGFGLGLDLNNLKQEDLEKAI 414
            ||..:.||:|||.....|::|.|.|::|:|.|.||..|:...:..|..:.||.:.:...||..|:
Human   365 HPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTMSSTDLLNAL 429

  Fly   415 QTLLTDPSYAKASLAISERYRDQPQSAVDRAVWWTEYVIRHNGAPHLRATSRDLNFIQLNSLDTL 479
            :|::.||.|.:.::.:|..:.|||...:||||:|.|:|:||.||.|||..:.||.:.|.:|||..
Human   430 KTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVT 494

  Fly   480 AVILA-VPLLLALLIVTLSCK---LLGGKKQK 507
            ..:|| |..::.::...|.|.   :..|||.|
Human   495 GFLLACVATVIFIITKCLFCVWKFVRTGKKGK 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35C1	NP_001097744.1	Glycosyltransferase_GTB-type	45..477	CDD:471961	142/478 (30%)
UGT2B4	NP_066962.2	UDPGT	24..524	CDD:278624	154/532 (29%)