Protein Alignment Ugt35C1 and UGT1A3

DIOPT Version :10

• Sequence 1: NP_001097744.1
• Gene: Ugt35C1 / 53507
• FlyBaseID: FBgn0040256
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_061966.1
• Gene: UGT1A3 / 54659
• HGNCID: 12535
• Length: 534
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 158/550 - (28%)
• Similarity: 261/550 - (47%)
• Gaps: 81/550 - (14%)

  Fly    14 LSAKPLESESAKILATLPFPGRSQYIFVESYLKALAAKGHQVTVINAFKNKETPNMRFIEALKAH 78
            ||.:|. :||.|:| .:|..| |.::.:...|:.|.|:|||..|:       ||.:..      |
Human    20 LSVQPW-AESGKVL-VVPIDG-SHWLSMREVLRELHARGHQAVVL-------TPEVNM------H 68

  Fly    79 EFADEMMSLLNVPLLWQQ-------------LNAMDYILNKFIDVTMEDEGVQRLLNSGETFDLV 130
            ...:...:|....:.|.|             ....::.|.||.      ..:..|.|....:...
Human    69 IKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFF------RSMAMLNNMSLVYHRS 127

  Fly   131 LAEMLHMEPMYAFAQHFNATLVGFSSFGTDRTIDEAAG---------------NI---------- 170
            ..|:||.|   |..:|.|||  .|....|| .::..|.               ||
Human   128 CVELLHNE---ALIRHLNAT--SFDVVLTD-PVNLCAAVLAKYLSIPTVFFLRNIPCDLDFKGTQ 186

  Fly   171 --SPISYNPLVTSPRTDRMTFLERLENHYEVIVEDIHRHFVHLPHMRNVYKKYFPNAKKTLEEVM 233
              :|.||.|.:.:..:|.|||::|::|....:......|....|: .::..:.| ..:.::.:::
Human   187 CPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPY-ASLASELF-QREVSVVDIL 249

  Fly   234 DSFSLILLGQHFSLSYPRPYLPNMIEVGGMHISHKPKPLPEDIKQFIEGS-PHGVIYFSMGSNVK 297
            ...|:.|....|.:.||||.:|||:.:||::.::: |||.::.:.:|..| .||::.||:||.|
Human   250 SHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANR-KPLSQEFEAYINASGEHGIVVFSLGSMV- 312

  Fly   298 SKDLPQETRDTLLKTFAKLKQRVLWKFEDDDMPGKPANVLIKKWYPQPDILAHPNVKLFISHGGL 362
             .::|::....:.....|:.|.|||::..........|.::.||.||.|:|.||..:.||:|.|.
Human   313 -SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGS 376

  Fly   363 LSSTESVYFGKPILGLPCFYDQHMNVQRAQRVGFGLGLDLNNLKQEDLEKAIQTLLTDPSYAKAS 427
            ....||:..|.|::.:|.|.||..|.:|.:..|.|:.|::..:..||||.|::.::.|.||.:..
Human   377 HGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENI 441

  Fly   428 LAISERYRDQPQSAVDRAVWWTEYVIRHNGAPHLRATSRDLNFIQLNSLDTLAVILAVPLLLALL 492
            :.:|..::|:|...:|.||:|.|:|:||.||||||..:.||.:.|.:|||.:..:|||.|.:|
Human   442 MRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVA-- 504

  Fly   493 IVTLSCKLLG-----GKKQKCLHADKLKKH 517
            .:|..|...|     |||.:...|.|.|.|
Human   505 FITFKCCAYGYRKCLGKKGRVKKAHKSKTH 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35C1	NP_001097744.1	Glycosyltransferase_GTB-type	45..477	CDD:471961	131/472 (28%)
UGT1A3	NP_061966.1	UDPGT	29..525	CDD:278624	149/529 (28%)