Protein Alignment Ugt35C1 and UGT1A1

DIOPT Version :10

• Sequence 1: NP_001097744.1
• Gene: Ugt35C1 / 53507
• FlyBaseID: FBgn0040256
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_000454.1
• Gene: UGT1A1 / 54658
• HGNCID: 12530
• Length: 533
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 161/545 - (29%)
• Similarity: 266/545 - (48%)
• Gaps: 56/545 - (10%)

  Fly     6 VIAIVFCALSAKPLESESAKILATLPFPGRSQYIFVESYLKALAAKGHQVTVI----------NA 60
            |:.::.|.|.  |:.|.:.||| .:|..| |.::.:...::.|..:||::.|:          .|
Human    12 VLGLLLCVLG--PVVSHAGKIL-LIPVDG-SHWLSMLGAIQQLQQRGHEIVVLAPDASLYIRDGA 72

  Fly    61 FKNKETPNMRFIEALKAHEFADEMMSLLNVPLLWQQLNAMDYILNKFI--------DVTMEDEGV 117
            |...:|..:.|    :..:..:..:|      |...:...|..|.:.|        |..|...|.
Human    73 FYTLKTYPVPF----QREDVKESFVS------LGHNVFENDSFLQRVIKTYKKIKKDSAMLLSGC 127

  Fly   118 QRLLNSGE--------TFDLVLAE-MLHMEPMYAFAQHFNATLVGFSSFGTDRTIDEAAGNISPI 173
            ..||::.|        :||::|.: .|...|:  .||:.:...|.|..........||....:|.
Human   128 SHLLHNKELMASLAESSFDVMLTDPFLPCSPI--VAQYLSLPTVFFLHALPCSLEFEATQCPNPF 190

  Fly   174 SYNPLVTSPRTDRMTFLERLENHYEVIVEDIHRHFVHLPHMRNVYKKYFPNAKKTLEEVMDSFSL 238
            ||.|...|..:|.||||:|::|......::.....|:.|:.  .....|...:.|:::::.|.|:
Human   191 SYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYA--TLASEFLQREVTVQDLLSSASV 253

  Fly   239 ILLGQHFSLSYPRPYLPNMIEVGGMHISHKPKPLPEDIKQFIEGS-PHGVIYFSMGSNVKSKDLP 302
            .|....|...||||.:|||:.|||::..|: .||.::.:.:|..| .||::.||:||.|  .::|
Human   254 WLFRSDFVKDYPRPIMPNMVFVGGINCLHQ-NPLSQEFEAYINASGEHGIVVFSLGSMV--SEIP 315

  Fly   303 QETRDTLLKTFAKLKQRVLWKFEDDDMPGKPANVLIKKWYPQPDILAHPNVKLFISHGGLLSSTE 367
            ::....:.....|:.|.|||::..........|.::.||.||.|:|.||..:.||:|.|.....|
Human   316 EKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYE 380

  Fly   368 SVYFGKPILGLPCFYDQHMNVQRAQRVGFGLGLDLNNLKQEDLEKAIQTLLTDPSYAKASLAISE 432
            |:..|.|::.:|.|.||..|.:|.:..|.|:.|::..:..||||.|::.::.|.||.:..:.:|.
Human   381 SICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSS 445

  Fly   433 RYRDQPQSAVDRAVWWTEYVIRHNGAPHLRATSRDLNFIQLNSLDTLAVILAVPLLLALLIVTLS 497
            .::|:|...:|.||:|.|:|:||.||||||..:.||.:.|.:|||.:..:|||.|.:|  .:|..
Human   446 LHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVA--FITFK 508

  Fly   498 CKLLG-----GKKQKCLHADKLKKH 517
            |...|     |||.:...|.|.|.|
Human   509 CCAYGYRKCLGKKGRVKKAHKSKTH 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35C1	NP_001097744.1	Glycosyltransferase_GTB-type	45..477	CDD:471961	133/459 (29%)
UGT1A1	NP_000454.1	UDPGT	28..524	CDD:278624	152/516 (29%)