Protein Alignment Ugt35C1 and UGT1A9

DIOPT Version :10

• Sequence 1: NP_001097744.1
• Gene: Ugt35C1 / 53507
• FlyBaseID: FBgn0040256
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_066307.1
• Gene: UGT1A9 / 54600
• HGNCID: 12541
• Length: 530
• Species: Homo sapiens
• Alignment Length: 571
• Identity: 160/571 - (28%)
• Similarity: 263/571 - (46%)
• Gaps: 109/571 - (19%)

  Fly     4 LTVIAIVFCALSAKPLESESAKILATLPFPGRSQYIFVESYLKALAAKGHQVTVI---------- 58
            |.|..::.|..      :|:.|:| .:|..| |.:..:.|.::.|..:||:|.|:
Human    12 LCVCLLLTCGF------AEAGKLL-VVPMDG-SHWFTMRSVVEKLILRGHEVVVVMPEVSWQLGR 68

  Fly    59 ----------------------NAFKNKE-TPNMRFIEALKAHEFADEM-MSLLNVPLLWQQLNA 99
                                  .||.:.: ...:|.|.:|....:.|.. :...|...|::....
Human    69 SLNCTVKTYSTSYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYNDIFDLFFSNCRSLFKDKKL 133

  Fly   100 MDYILNKFIDVTMEDEGVQRLLNSGETFD---LVLAEMLHMEPMYAFAQ----HFNATLVGFSSF 157
            ::|:.....|....|           .||   |::|:...: |...||:    |:
Human   134 VEYLKESSFDAVFLD-----------PFDNCGLIVAKYFSL-PSVVFARGILCHY---------- 176

  Fly   158 GTDRTIDEAAGNISPISYNPLVTSPRTDRMTFLERLENHYEVIVEDIHRHFVHLPHMRNVYKKYF 222
                 ::|.|...:|:||.|.:....:|.|||.||:.||...:.|.:..|            ::|
Human   177 -----LEEGAQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLLCH------------RFF 224

  Fly   223 PNAKKTLEEVMDS----------FSLILLGQHFSLSYPRPYLPNMIEVGGMHISHKPKPLPEDIK 277
            .||.:...|::.:          .|:.||...|.|.||:|.:||||.:||:: .|:.||||.:.:
Human   225 KNALEIASEILQTPVTEYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGIN-CHQGKPLPMEFE 288

  Fly   278 QFIEGS-PHGVIYFSMGSNVKSKDLPQETRDTLLKTFAKLKQRVLWKFEDDDMPGKPANVLIKKW 341
            .:|..| .||::.||:||.|  .::|::....:.....|:.|.|||::..........|.::.||
Human   289 AYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKW 351

  Fly   342 YPQPDILAHPNVKLFISHGGLLSSTESVYFGKPILGLPCFYDQHMNVQRAQRVGFGLGLDLNNLK 406
            .||.|:|.||..:.||:|.|.....||:..|.|::.:|.|.||..|.:|.:..|.|:.|::..:.
Human   352 LPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT 416

  Fly   407 QEDLEKAIQTLLTDPSYAKASLAISERYRDQPQSAVDRAVWWTEYVIRHNGAPHLRATSRDLNFI 471
            .||||.|::.::.|.||.:..:.:|..::|:|...:|.||:|.|:|:||.||||||..:.||.:.
Human   417 SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWY 481

  Fly   472 QLNSLDTLAVILAVPLLLALLIVTLSCKLLG-----GKKQKCLHADKLKKH 517
            |.:|||.:..:|||.|.:|  .:|..|...|     |||.:...|.|.|.|
Human   482 QYHSLDVIGFLLAVVLTVA--FITFKCCAYGYRKCLGKKGRVKKAHKSKTH 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35C1	NP_001097744.1	Glycosyltransferase_GTB-type	45..477	CDD:471961	133/483 (28%)
UGT1A9	NP_066307.1	UDPGT	26..521	CDD:278624	152/540 (28%)