Protein Alignment Ugt35C1 and UGT1A6

DIOPT Version :10

• Sequence 1: NP_001097744.1
• Gene: Ugt35C1 / 53507
• FlyBaseID: FBgn0040256
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_001063.2
• Gene: UGT1A6 / 54578
• HGNCID: 12538
• Length: 532
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 152/540 - (28%)
• Similarity: 253/540 - (46%)
• Gaps: 85/540 - (15%)

  Fly    27 LATLPFPGRSQYIFVESYLKALAAKGHQVTVI--------------------------------N 59
            |..:|..| |.::.::..::.|:.:||::.|:                                .
Human    29 LLVVPQDG-SHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLKESKYYTRKIYPVPYDQEELKNRYQ 92

  Fly    60 AFKNKETPNMRFIEALKAHEFADEMMSL----LNVPLLWQQLNAMDYILNKFIDVTMEDEGVQRL 120
            :|.|.......|:.|.:. |:.:.|:.:    :|...|.|..:.:::......|....|..
Human    93 SFGNNHFAERSFLTAPQT-EYRNNMIVIGLYFINCQSLLQDRDTLNFFKESKFDALFTDPA---- 152

  Fly   121 LNSGETFDLVLAEMLHMEPMYAFAQHFNATLVGFSSFGTDRTIDEAAGNISPISYNPLVTSPRTD 185
            |..|    ::|||.|.:..:|.| :.|..:|....|...|           |:||.|...:..:|
Human   153 LPCG----VILAEYLGLPSVYLF-RGFPCSLEHTFSRSPD-----------PVSYIPRCYTKFSD 201

  Fly   186 RMTFLERLENHYEVIVEDIHRHFVHLPHM-RNVYKKYFPNAKKTLEEVMDSFSLI------LLGQ 243
            .|||.:|:.|....::|         |:: ..::.||...|...|:..:|..:|.      ||..
Human   202 HMTFSQRVANFLVNLLE---------PYLFYCLFSKYEELASAVLKRDVDIITLYQKVSVWLLRY 257

  Fly   244 HFSLSYPRPYLPNMIEVGGMHISHKPKPLPEDIKQFIEGS-PHGVIYFSMGSNVKSKDLPQETRD 307
            .|.|.||||.:|||:.:||::.. |.|.|.::.:.:|..| .||::.||:||.|  .::|::...
Human   258 DFVLEYPRPVMPNMVFIGGINCK-KRKDLSQEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAM 319

  Fly   308 TLLKTFAKLKQRVLWKFEDDDMPGKPANVLIKKWYPQPDILAHPNVKLFISHGGLLSSTESVYFG 372
            .:.....|:.|.|||::..........|.::.||.||.|:|.||..:.||:|.|.....||:..|
Human   320 AIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNG 384

  Fly   373 KPILGLPCFYDQHMNVQRAQRVGFGLGLDLNNLKQEDLEKAIQTLLTDPSYAKASLAISERYRDQ 437
            .|::.:|.|.||..|.:|.:..|.|:.|::..:..||||.|::.::.|.||.:..:.:|..::|:
Human   385 VPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDR 449

  Fly   438 PQSAVDRAVWWTEYVIRHNGAPHLRATSRDLNFIQLNSLDTLAVILAVPLLLALLIVTLSCKLLG 502
            |...:|.||:|.|:|:||.||||||..:.||.:.|.:|||.:..:|||.|.:|  .:|..|...|
Human   450 PVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVA--FITFKCCAYG 512

  Fly   503 -----GKKQKCLHADKLKKH 517
                 |||.:...|.|.|.|
Human   513 YRKCLGKKGRVKKAHKSKTH 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35C1	NP_001097744.1	Glycosyltransferase_GTB-type	45..477	CDD:471961	131/475 (28%)
UGT1A6	NP_001063.2	UDPGT	27..523	CDD:278624	148/529 (28%)